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C2542

Sigma-Aldrich

Monoclonal Anti-N-Cadherin antibody produced in mouse

clone GC-4, ascites fluid

Synonim(y):

Anti-A-CAM, Anti-A-Cell Adhesion Molecule

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About This Item

Numer MDL:
MFCD00164511
Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

mouse

Poziom jakości

200

białko sprzężone

unconjugated

forma przeciwciała

ascites fluid

rodzaj przeciwciała

primary antibodies

klon

GC-4, monoclonal

zawiera

15 mM sodium azide

reaktywność gatunkowa

chicken, mouse, human, rabbit, rat

metody

electron microscopy: suitable
immunohistochemistry (frozen sections): 1:100 using chicken cardiac muscle
microarray: suitable
western blot: 1:100 using chicken or rat cardiac muscle

numer dostępu UniProt

P19022

Zastosowanie

research pathology

Warunki transportu

dry ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... CDH2(1000)
mouse ... Cdh2(12558)
rat ... Cdh2(83501)

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Opis ogólny

N-cadherin is a calcium dependent cell adhesion molecule and is present mainly in cancer cells. Monoclonal anti-N-cadherin antibody reacts with the N-terminal portion of the extracellular domain of adipocyte adhesion molecule (ACAM).

Specyficzność

Monoclonal anti-N-cadherin antibody reacts specifically with A-CAM molecule in human, mouse, rabbit, chicken and rat.

Immunogen

Affinity purified chicken heart A-CAM.

Zastosowanie

Monoclonal anti-N-cadherin antibody can be used in immunofluorescent microscopy, electron microscopy and immunoblotting to study the receptor localization of intercellular adherens. It may also be used to study the mechanism of adhesion and interaction in tissues.
Monoclonal anti-N-cadherin antibody can be used in immunohistochemistry (1: 100) and as primary antibody in western blotting (1:1000) .

Działania biochem./fizjol.

N-cadherin regulates the Src kinase pathway and also promotes cell motility and invasion. It inhibits adherens junction formation and disrupts existing junctions of cultured lens cells.

Postać fizyczna

Monoclonal Anti-N-Cadherin antibody produced in mouse is supplied as ascites fluid containing 15mM sodium azide.

Przechowywanie i stabilność

For continuous use, store at 2-8 °C for up to one month. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

nwg

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Kamiel A J Kuijpers et al.
BioMed research international, 2014, 754596-754596 (2014-05-16)
The human bladder shows spontaneous autonomous activity. Detrusor overactivity could be seen as a consequence of exaggerated autonomous activity. Interstitial cells (ICs) play a potential role in coordination of autonomous activity. As it is suggested that changes in ICs coexist
Balázs Hegedüs et al.
Biophysical journal, 91(7), 2708-2716 (2006-07-11)
Impairment of tissue cohesion and the reorganization of the extracellular matrix are crucial events during the progression toward invasive cell phenotype. We studied the in vitro invasion patterns of nine brain tumor cell lines in three-dimensional collagen gels. Cell-cell and
Ignacio Ramis-Conde et al.
Physical biology, 6(1), 016008-016008 (2009-03-27)
Transendothelial migration is a crucial process of the metastatic cascade in which a malignant cell attaches itself to the endothelial layer forming the inner wall of a blood or lymph vessel and creates a gap through which it enters into
Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis
Hazan RB
The Journal of cell biology, 148(4), 779-790 (2000)
Kamiel A J Kuijpers et al.
BioMed research international, 2014, 464217-464217 (2014-04-11)
Interstitial cells, also called myofibroblasts, most probably play a major role in the pathogenesis of the overactive bladder. However, no specific phenotypic marker has been identified. We investigated whether N-cadherin could play a role as a discriminatory marker for interstitial
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