C3865

Anti-N-Cadherin antibody, Mouse monoclonal

clone GC-4, purified from hybridoma cell culture

• Synonim(y): Anti-A-CAM, Anti-A-Cell Adhesion Molecule
• Numer MDL: MFCD00164511
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: mouse
• białko sprzężone: unconjugated
• forma przeciwciała: purified immunoglobulin
• rodzaj przeciwciała: primary antibodies
• klon: GC-4, monoclonal
• Formularz: buffered aqueous solution
• masa cząsteczkowa: antigen 135 kDa
• reaktywność gatunkowa: chicken, monkey, mouse, human, rabbit, rat
• metody: electron microscopy: suitable; flow cytometry: suitable; immunocytochemistry: suitable; immunohistochemistry: 10-20 μg/mL using rat cardiac muscle frozen sections; western blot: 10-20 μg/mL using chicken cardiac muscle or COS-7 cell extracts
• izotyp: IgG1
• numer dostępu UniProt: P19022
• Zastosowanie: research pathology
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... CDH2(1000) ; mouse ... Cdh2(12558) ; rat ... Cdh2(83501)

Opis

Opis ogólny

N-Cadherin is a member of the cadherin family of proteins that mediate cell-cell adhesion in a calcium dependent manner. N-cadherin is a transmembrane glycoprotein that localizes in the cell-cell adherens junction on the plasma membrane. The protein is known to be localized in the cell membrane.

Zastosowanie

Anti-N-Cadherin antibody is suitable for the following procedures:

• electron microscopy
• flow cytometry
• immunocytochemistry
• immunohistochemistry at a concentration of 10-20μg/mL using rat cardiac muscle frozen sections
• western blot at a concentration of 10-20μg/mL using chicken cardiac muscle or COS-7 cell extracts

Działania biochem./fizjol.

CDH11 gene encodes a type II classical cadherin that mediate calcium-dependent cell-cell adhesion.

Higher expression of CDH2 gene was observed in tumor cells. It is known to induce the invasive and chemoresistant attributes to the cancer cells. N-glycosylation of N-cadherin is associated with the process of tumorigenesis especially in mammary gland, renal system, and ovary. Loss of expression of the gene was observed in adrenocortical carcinoma.

Postać fizyczna

0.2 μm-filtered solution in 0.01 M phosphate buffered saline, pH 7.4.

Inne uwagi

Clone GC-4 is also known as GB-9.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves