C221

Carboxy-PTIO potassium salt

• Synonim(y): 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt, 2-(4-Carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazol-1-yloxy-3-oxide potassium salt
• Wzór empiryczny (zapis Hilla): C₁₄H₁₆KN₂O₄
• Numer CAS: 148819-94-7
• Masa cząsteczkowa: 315.39
• Numer MDL: MFCD00216153
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24892474
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: synthetic (organic)
• Poziom jakości: 100
• Próba: ≥98% (TLC)
• Formularz: powder
• mp: >270 °C
• rozpuszczalność: H₂O: 100 mg/mL; DMSO: soluble (lit.)(lit.); methanol: soluble (lit.)(lit.)
• temp. przechowywania: 2-8°C
• ciąg SMILES: [K+].CC1(C)N([O])C(c2ccc(cc2)C([O-])=O)=[N+]([O-])C1(C)C
• InChI: 1S/C14H17N2O4.K/c1-13(2)14(3,4)16(20)11(15(13)19)9-5-7-10(8-6-9)12(17)18;/h5-8H,1-4H3,(H,17,18);/q;+1/p-1
• Klucz InChI: VYEUQMVIGXFZQU-UHFFFAOYSA-M

Opis

Opis ogólny

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO) is mainly considered as a scavenger of nitric oxide (NO).

Zastosowanie

Carboxy-PTIO potassium salt has been used to check the generation of hydroxyl radicals or nitric in reaction mixtures to examine the generation of nitric oxide in reaction mixture. It has also been added to neurons to analyse its effect on glucose/oxygen/serum deprivation (GOSD) condition(4)

Działania biochem./fizjol.

Carboxy-PTIO can make a quick reaction with nitric oxide (NO) to produce nitrogen dioxide (NO₂). It can be used to prevent hypotension and endotoxic shock, stimulated by lipopolysaccharide in- vivo. Carboxy-PTIO can also block in vitro vascular relaxation, stimulated by NO.

Reacts with nitric oxide to form carboxy-PTI derivatives which in turn inhibits nitric oxide synthase.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)