A4941

Activin A human

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

• Synonim(y): Activin A Protein, Growth Factor, Human Growth Factor
• Numer WE: 201-069-1
• Numer MDL: MFCD02685750
• Kod UNSPSC: 12352202
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: human
• Poziom jakości: 200
• rekombinowane: expressed in baculovirus infected insect cells
• Próba: ≥95% (SDS-PAGE)
• Postać: lyophilized powder
• siła działania: 1-10 ng/mL ED₅₀
• masa cząsteczkowa: dimer 26 kDa (containing 116 amino acid residues βA subunits)
• opakowanie: pkg of 10 μg; pkg of 5 μg
• metody: cell culture | mammalian: suitable
• zanieczyszczenia: endotoxin, tested
• numer dostępu UniProt: P08476
• temp. przechowywania: −20°C
• informacje o genach: human ... INHBA(3624)

Opis

Opis ogólny

Activin A gene with two exons is mapped to human chromosome 2q35. Activin A also known as inhibin α-subunit belongs to the TGF-β (transforming growth factor-β) superfamily of proteins and its expression is exclusive to gonads, placenta and adrenal cortex.

Zastosowanie

Activin A human has been used as a constituent of modified barth′s saline used in in vitro induction of pronephros. It has also been used as a constituent of Roswell Park memorial institute (RPMI) media to induce pancreatic differentiation of multipotent dermal fibroblasts in vitro.

Działania biochem./fizjol.

Activins play a vital role in the regulation of hormonogenesis, cellular homeostasis and differentiation programs. Elevated expression of activin A and B leads to the loss of muscle mass. Both activin A and B have a potential to act as a serum markers of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

Postać fizyczna

Lyophilized from 0.2 μm filtered solution in 10 mM sodium citrate, pH 3.0.

Komentarz do analizy

The biological activity is determined by its ability to inhibit the proliferation of mouse MPC-11 cells.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H319,H335
• Zwroty wskazujące środki ostrożności: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Eye Irrit. 2 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable