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Key Documents

SRP3276

Sigma-Aldrich

SDF-1 ALPHA human

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonim(y):

CXCL12, PBSF

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About This Item

Kod UNSPSC:
12352202
NACRES:
NA.32

pochodzenie biologiczne

human

rekombinowane

expressed in E. coli

Próba

≥98% (HPLC)
≥98% (SDS-PAGE)

Postać

lyophilized

siła działania

20.0-80.0 ng/mL

masa cząsteczkowa

8.0 kDa

opakowanie

pkg of 10 μg

zanieczyszczenia

<0.1 EU/μg endotoxin, tested

kolor

white

numer dostępu UniProt

Warunki transportu

wet ice

temp. przechowywania

−20°C

informacje o genach

human ... CXCL12(6387)

Opis ogólny

SDF-1α (stromal cell-derived factor 1 α) and β are stromal derived CXC chemokines, and signal through the CXCR4 (C-X-C motif chemokine receptor). SDF1α is an isoform of CXCL12 (C-X-C motif chemokine 12, also referred to as SDF-1). The gene is mapped to human chromosome 10q11. Recombinant human SDF-1a is an 8.0kDa protein containing 68 amino acid residues.

Zastosowanie

SDF-1α (stromal cell-derived factor 1 α) human has been used to study the role of SDF-1α in cell migration and survival after TGF (transforming growth factor)-β-induced EMT (epithelial–mesenchymal transition) in hepatoma cells. It has been used to study podia formation, migration, proliferation and cell-cell adhesion of human hematopoietic progenitor cells in presence of SDF-1α.
SDF-1α (stromal cell-derived factor 1 α) human has been used in the chemotaxis assay of neural crest cells (NCCs) and as a component of Dulbecco′s modified Eagle′s medium (DMEM) in migration assay of human mesenchymal stem cells (hMSCs).

Działania biochem./fizjol.

SDF-1α (stromal cell-derived factor 1 α) and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. SDF-1 is mainly expressed in the inflamed and failing myocardium. It is involved in inflammation, proliferation, tumorigenicity and metastasis. The SDF-1 proteins exert HIV (human immunodeficiency virus) suppressive activity in cells expressing the CXCR4 (C-X-C motif chemokine receptor 4). It is upregulated in breast carcinoma, ovarian carcinoma and papillary thyroid carcinoma. It enhances angiogenesis in the ischemic tissue. SDF1 is also involved in neuroprotection after ischemic stroke with the help of CXCR4.

Postać fizyczna

Lyophilized with no additives.

Rekonstytucja

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
Bleul CC
The Journal of Experimental Medicine, 184, 1101-1109 (1996)
The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells.
Faber A
Journal of Biomedicine and Biotechnology, 2007, 26065-26065 (2007)
Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo
Kotini M, et al.
Nature Communications, 9(1), 3846-3846 (2018)
The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood.
Aiuti A
The Journal of Experimental Medicine, 185, 111-120 (1997)
Stromal cell-derived factor 1a (SDF-1a): A marker of disease burden in patients with atrial fibrillation.
Li D
Scandinavian Cardiovascular Journal : SCJ, 50, 36-41 (2016)

Produkty

Omówiono biomateriały na bazie hydrożeli do dostarczania komórek i regeneracji tkanek.

The use of hydrogel-based biomaterials for the delivery and recruitment of cells to promote tissue regeneration in the body is of growing interest. This article discussed the application of hydrogels in cell delivery and tissue regeneration.

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