477R-1

MAGEC2 (EP405) Rabbit Monoclonal Primary Antibody

• Synonim(y): Melanoma-associated antigen C2
• Kod UNSPSC: 12352203

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100; 500
• białko sprzężone: unconjugated
• forma przeciwciała: culture supernatant
• rodzaj przeciwciała: primary antibodies
• klon: EP405, monoclonal
• opis: For In Vitro Diagnostic Use in Select Regions
• Postać: buffered aqueous solution
• reaktywność gatunkowa: human
• opakowanie: vial of 0.1 mL concentrate (477R-14); vial of 0.1 mL concentrate Research Use Only (477R-14-RUO); vial of 0.5 mL concentrate (477R-15); vial of 1.0 mL concentrate (477R-16); vial of 1.0 mL concentrate Research Use Only (477R-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (477R-17-RUO); vial of 1.0 mL pre-dilute ready-to-use (477R-17); vial of 7.0 mL pre-dilute ready-to-use (477R-18); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (477R-18-RUO)
• producent / nazwa handlowa: Cell Marque^™
• metody: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)
• izotyp: IgG
• kontrola: seminoma
• Warunki transportu: wet ice
• temp. przechowywania: 2-8°C
• wizualizacja: nuclear

Opis

Opis ogólny

Melanoma-associated antigen C2 (MAGEC2), encoded by the testis cancer gene CT10, belongs to a family of proteins that bind E3 RING ubiquitin ligases via a common MAGE homology domain.^1-3 The MAGE-RING complexes that are formed enhance the activity of the ubiquitin ligase binding partners. In vitro studies suggest that MAGEC2, which binds to TRIM28, is involved in tumorigenesis through the increased degradation of p53.⁴ In germ cell tumors, aberrant expression of MAGEC2 is exhibited in seminomas, but is absent in yolk sac tumor and embryonal carcinoma.^5-7

Jakość

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Postać fizyczna

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Uwaga dotycząca przygotowania

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Inne uwagi

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informacje prawne

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 2