456R-3

IDH1 R132H (MRQ-67) Rabbit Monoclonal Antibody

• Synonim(y): Isocitrate dehydrogenase 1
• Kod UNSPSC: 12352203

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100; 500
• białko sprzężone: unconjugated
• forma przeciwciała: culture supernatant
• rodzaj przeciwciała: primary antibodies
• klon: MRQ-67, monoclonal
• opis: For In Vitro Diagnostic Use in Select Regions
• Postać: buffered aqueous solution
• reaktywność gatunkowa: human
• opakowanie: vial of 0.1 mL concentrate (456R-34); vial of 0.1 mL concentrate, Research Use Only (456R-34-RUO); vial of 0.5 mL concentrate (456R-35); vial of 1.0 mL concentrate (456R-36); vial of 1.0 mL concentrate, Research Use Only (456R-36-RUO); vial of 1.0 mL pre-dilute ready-to-use (456R-37); vial of 1.0 mL pre-dilute, Research Use Only (456R-37-RUO); vial of 7.0 mL pre-dilute ready-to-use (456R-38); vial of 7.0 mL pre-dilute, ready-to-use, Research Use Only (456R-38-RUO)
• producent / nazwa handlowa: Cell Marque^™
• metody: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)
• izotyp: IgG
• kontrola: acute myeloid leukemia, astrocytoma, glioblastoma, oligodendroglioma
• Warunki transportu: wet ice
• temp. przechowywania: 2-8°C
• wizualizacja: cytoplasmic
• informacje o genach: human ... IDH1(3417)

Opis

Opis ogólny

Isocitrate dehydrogenase 1 (IDH1) functions as an enzyme in the Krebs (citric acid) cycle and is biologically active in the cytoplasmic and peroxisomal compartments under normal conditions. The occurrence of heterozygous missense mutations at an arginine residue at codon 132 (R132) within the coding region for the substrate binding site of IDH1 has been described to promote oncogenesis in several malignancies. Of the identified mutant variants, a histidine substitution (R132H) is one of the more frequently observed point mutations in certain tumor groups of gliomas. Mutations involving IDH1 have been implicated as early events during gliomagenesis and IDH1 mutation status was incorporated into the 2016 WHO Classification of Tumors of the Central Nervous System as a new parameter for sub-classifying diffuse astrocytic and oligodendrogliomal tumors.^3,4 Immunohistochemical identification of IDH1 R132H immunoreactivity can be used as a tool in screening tumors that may be harboring this mutation, such as low grade diffuse and anaplastic astrocytomas, oligodendrogliomas, and secondary glioblastomas.

Jakość

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Postać fizyczna

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Uwaga dotycząca przygotowania

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Inne uwagi

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informacje prawne

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable