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Y0000016

Propofol

European Pharmacopoeia (EP) Reference Standard

Synonim(y):

2,6-Diisopropylphenol, 2,6-Bis(1-methylethyl)phenol, 2,6-Bis(isopropyl)phenol, Propofol

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About This Item

Wzór liniowy:
[(CH3)2CH]2C6H3OH
Numer CAS:
2078-54-8
Masa cząsteczkowa:
178.27
Numer MDL:
MFCD00008885
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
329830815
NACRES:
NA.24

klasa czystości

pharmaceutical primary standard

ciśnienie pary

5.6 mmHg ( 100 °C)

rodzina API

propofol

producent / nazwa handlowa

EDQM

współczynnik refrakcji

n20/D 1.514 (lit.)

bp

256 °C/764 mmHg (lit.)

mp

18 °C (lit.)

gęstość

0.962 g/mL at 25 °C (lit.)

Zastosowanie

pharmaceutical (small molecule)

Format

neat

temp. przechowywania

2-8°C

ciąg SMILES

CC(C)c1cccc(C(C)C)c1O

InChI

1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3

Klucz InChI

OLBCVFGFOZPWHH-UHFFFAOYSA-N

informacje o genach

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

Propofol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Opakowanie

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Inne uwagi

Sales restrictions may apply.
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PHR2565

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PHR2566

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Piktogramy

Exclamation mark
GHS07

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H302,H315,H319,H335

Klasyfikacja zagrożeń

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organy docelowe

Respiratory system

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

235.4 °F - closed cup

Temperatura zapłonu (°C)

113 °C - closed cup

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Propofol Related Compound C

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Cynthia Ménard et al.
Radiology, 274(1), 181-191 (2014-09-10)
To determine if the integration of diagnostic magnetic resonance (MR) imaging and MR-guided biopsy would improve target delineation for focal salvage therapy in men with prostate cancer. Between September 2008 and March 2011, 30 men with biochemical failure after radiation
Emily Black et al.
The Annals of pharmacotherapy, 47(6), 856-868 (2013-05-23)
To evaluate the efficacy and safety of propofol compared to other agents for procedural sedation of adults in the emergency department (ED) and to review the use of opioids in conjunction with propofol for procedural sedation in the ED. PubMed
A J Thomson et al.
Anaesthesia, 69(5), 420-428 (2014-04-18)
Debate continues over the most appropriate blood-brain equilibration rate constant (ke0) for use with the Marsh pharmacokinetic model for propofol. We aimed to define the optimal ke0 value. Sixty-four patients were sedated with incremental increases in effect-site target concentration of
Muhammad Suleman Khan et al.
Basic & clinical pharmacology & toxicology, 115(6), 565-570 (2014-06-04)
A variety of techniques have been developed to monitor the depth of anaesthesia. Propofol's pharmacokinetics and response vary greatly, which might be explained by genetic polymorphisms. We investigated the impact of genetic variations on dosage, anaesthetic depth and recovery after
S Bache et al.
British journal of anaesthesia, 110(5), 741-746 (2012-12-22)
Over a 5 yr period, we have encountered three patients in whom remifentanil appeared to have no clinical effect during general anaesthesia (GA). We describe seven anaesthetics in these three patients. We reviewed the literature on this subject. A simple
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