PHR1883

Docetaxel

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonim(y): Docetaxel trihydrate
• Wzór empiryczny (zapis Hilla): C₄₃H₅₃NO₁₄ · 3H₂O
• Numer CAS: 148408-66-6
• Masa cząsteczkowa: 861.93
• Kod UNSPSC: 41116107
• NACRES: NA.24

Właściwości

• klasa czystości: certified reference material; pharmaceutical secondary standard
• Poziom jakości: 300
• agency: traceable to Ph. Eur. Y0001133; traceable to USP 1224551
• rodzina API: docetaxel
• Certyfikat analizy: current certificate can be downloaded
• opakowanie: pkg of 200 mg
• Zastosowanie: pharmaceutical
• Format: neat
• temp. przechowywania: 2-8°C
• InChI: 1S/C43H53NO14.3H2O/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45;;;/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52);3*1H2/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+;;;/m0.../s1
• Klucz InChI: XCDIRYDKECHIPE-QHEQPUDQSA-N

Opis

Opis ogólny

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Docetaxel is a taxoid anticancer agent that binds to β tubulin and promotes tubulin assembly into microtubles inducing cell-cycle arrest and apoptosis.

Zastosowanie

Docetaxel may be used as a pharmaceutical reference standard for the determination of the analyte in plasma samples by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Inne uwagi

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAB0750 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H319,H360F
• Zwroty wskazujące środki ostrożności: P202 - P264 - P280 - P305 + P351 + P338 - P308 + P313 - P337 + P313
• Klasyfikacja zagrożeń: Eye Irrit. 2 - Repr. 1B
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable