PHR1624

Cisplatin

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonim(y): cis-Diammineplatinum(II) dichloride, cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin
• Wzór liniowy: Pt(NH₃)₂Cl₂
• Numer CAS: 15663-27-1
• Masa cząsteczkowa: 300.05
• Numer WE: 239-733-8
• Numer MDL: MFCD00011623
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329823516
• NACRES: NA.24

Właściwości

• klasa czystości: certified reference material; pharmaceutical secondary standard
• Poziom jakości: 300
• agency: traceable to Ph. Eur. C2210000; traceable to USP 1134357
• rodzina API: cisplatin
• Certyfikat analizy: current certificate can be downloaded
• opakowanie: pkg of 200 mg
• metody: HPLC: suitable; gas chromatography (GC): suitable
• mp: 270 °C (lit.)
• Zastosowanie: pharmaceutical (small molecule)
• format: neat
• temp. przechowywania: 2-30°C
• ciąg SMILES: N.N.Cl[Pt]Cl
• InChI: 1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
• Klucz InChI: LXZZYRPGZAFOLE-UHFFFAOYSA-L

Opis

Opis ogólny

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Cisplatin is an antineoplastic drug used for the treatment of cancer patients with a variety of different malignancies.

Zastosowanie

Cisplatin may be used as an analytical reference standard for the determination of the analyte in plasma, cancer cell, and tumor samples by high-performance liquid chromatographic assay.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Działania biochem./fizjol.

Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Inne uwagi

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAB7778 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H300 - H315 - H317 - H319 - H334 - H335 - H350
• Zwroty wskazujące środki ostrożności: P202 - P261 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable