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Merck

PHR1036

Supelco

Pyridoxine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonim(y):

3-Hydroxy-4,5-bis (hydroxymethyl)-2-picoline hydrochloride, Adermine hydrochloride, PN HCl, Pyridoxol hydrochloride, Vitamin B6 hydrochloride

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About This Item

Wzór empiryczny (zapis Hilla):
C8H11NO3 · HCl
Numer CAS:
Masa cząsteczkowa:
205.64
Beilstein:
3632435
Numer WE:
Numer MDL:
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
NACRES:
NA.24

klasa czystości

certified reference material
pharmaceutical secondary standard

Poziom jakości

agency

traceable to BP 458
traceable to Ph. Eur. P4100000
traceable to USP 1587001

rodzina API

pyridoxine

Certyfikat analizy

current certificate can be downloaded

metody

HPLC: suitable
gas chromatography (GC): suitable

mp

214-215 °C (lit.)

Zastosowanie

pharmaceutical (small molecule)

format

neat

temp. przechowywania

2-30°C

ciąg SMILES

Cl[H].Cc1ncc(CO)c(CO)c1O

InChI

1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H

Klucz InChI

ZUFQODAHGAHPFQ-UHFFFAOYSA-N

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Opis ogólny

Pyridoxine hydrochloride is a water soluble vitamin, widely used for the prevention of peripheral neuropathy and central nervous system effects associated with therapy involving isoniazid. It is highly required for the formation of hemoglobin and is also mainly involved in carbohydrate, fat and amino acid metabolism.

Zastosowanie

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Pyridoxine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography and spectrophotometric techniques.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Inne uwagi

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAB3720 in the slot below. This is an example certificate only and may not be the lot that you receive.

Polecane produkty

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
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Piktogramy

Corrosion

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

Zwroty wskazujące środki ostrożności

Klasyfikacja zagrożeń

Eye Dam. 1

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


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Certyfikaty analizy (CoA)

Lot/Batch Number

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Simultaneous derivative spectrophotometric analysis of doxylamine succinate, pyridoxine hydrochloride and folic acid in combined dosage forms
Pathak A and Rajput JS
Indian Journal of Pharmaceutical Sciences, 70(4), 513-513 (2008)
Development and validation of RP-HPLC method for simultaneous determination of pyridoxine hydrochloride, isoniazid, pyrazinamide and rifampicin in pharmaceutical formulation
Dhal KS and Sharma R
Chem. Anal. (Warsaw), 54(6), 1487-1487 (2009)
Liat Ashkenazi-Hoffnung et al.
The Israel Medical Association journal : IMAJ, 15(1), 23-26 (2013-03-15)
Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries. To evaluate the efficacy and safety of a simple bi-daily treatment regimen
Manfred Eggersdorfer et al.
Angewandte Chemie (International ed. in English), 51(52), 12960-12990 (2012-12-05)
The discovery of vitamins as essential factors in the diet was a scientific breakthrough that changed the world. Diseases such as scurvy, rickets, beriberi, and pellagra were recognized to be curable with an adequate diet. These diseases had been prevalent
Sonia Fargue et al.
Biochimica et biophysica acta, 1832(10), 1776-1783 (2013-04-20)
Primary hyperoxaluria type 1 (PH1) is a rare hereditary calcium oxalate kidney stone disease caused by a deficiency of the liver-specific pyridoxal-phosphate-dependent peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT). About one third of patients are responsive to pharmacological doses of pyridoxine (vitamin

Protokoły

Oddzielanie chlorowodorku pirydoksyny (B6), wzorzec analityczny; chlorowodorek tiaminy (B1), wzorzec analityczny

Separation of Pyridoxine Hydrochloride (B6), analytical standard; Thiamine Hydrochloride (B1), analytical standard

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