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Dokumenty

P5654

Sigma-Aldrich

Piroxicam

≥98% (TLC)

Synonim(y):

4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide

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About This Item

Wzór empiryczny (zapis Hilla):
C15H13N3O4S
Numer CAS:
36322-90-4
Masa cząsteczkowa:
331.35
Numer WE:
252-974-3
Numer MDL:
MFCD00057317
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
24278641
NACRES:
NA.77

pochodzenie biologiczne

synthetic (organic)

Poziom jakości

100

Próba

≥98% (TLC)

Postać

powder

temp. przechowywania

2-8°C

ciąg SMILES

CN1C(C(=O)Nc2ccccn2)=C(O)c3ccccc3S1(=O)=O

InChI

1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)

Klucz InChI

QYSPLQLAKJAUJT-UHFFFAOYSA-N

informacje o genach

human ... PTGS1(5742) , PTGS2(5743)
rat ... Alox5(25290)

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Zastosowanie

Piroxicam has been used:
  • for the induction of colitis in mice
  • as a non-steroidal anti-inflammatory drug to increase the sensitivity to gut injury in interleukin-10 (IL-10) knockout mice
  • as a chemopreventive agent and as a positive control to study its effects on tumor growth in mice small intestine

Działania biochem./fizjol.

Piroxicam is a non‐steroidal anti‐inflammatory drug (NSAID). It possesses analgesic properties and exhibits therapeutic effects against rheumatic disorders.
Cyclooxygenase inhibitor.
This page may contain text that has been machine translated.

Piktogramy

Skull and crossbonesHealth hazard
GHS06,GHS08

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H301,H373

Zwroty wskazujące środki ostrożności

P260 - P264 - P270 - P301 + P310 - P314 - P405

Klasyfikacja zagrożeń

Acute Tox. 3 Oral - STOT RE 2 Oral

Organy docelowe

Gastrointestinal tract

Kod klasy składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Choose from one of the most recent versions:

Certyfikaty analizy (CoA)

Lot/Batch Number
STBK7363
STBK5168
STBK4154
STBK3784
SLCK4830

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Clonixin ≥98% (HPLC)

Sigma-Aldrich

SML0530

Clonixin

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Supelco

PHR1288

Gliclazide

Meloxicam A cell-permeable, non-steroidal anti-inflammatory drug (NSAID) of the oxicam family which preferentially inhibits the inducible isoform of COX-2 (IC₅₀ = 4.7 µM) relative to COX-1 (IC₅₀ = 36.6 µM).

Sigma-Aldrich

444800

Meloxicam

Lornoxicam ≥98% (HPLC)

Sigma-Aldrich

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vibrant-m

Y0001080

Meloxicam

Nimesulide

Sigma-Aldrich

N1016

Nimesulide

Etodolac

Sigma-Aldrich

E0516

Etodolac

Sulindac ≥98.0%

Sigma-Aldrich

S8139

Sulindac

Diflunisal analytical standard

Supelco

D3281

Diflunisal

Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling
Lang M, et al.
Molecular Cancer, 12(1), 41-41 (2013)
Jiawei Guo et al.
Cell reports. Medicine, 4(1), 100881-100881 (2023-01-06)
Systematic bone loss is commonly complicated with inflammatory bowel diseases (IBDs) with unclear pathogenesis and uncertain treatment. In experimental colitis mouse models established by dextran sulfate sodium and IL-10 knockout induced with piroxicam, bone mass and quality are significantly decreased.
T J Carty et al.
Prostaglandins, 19(1), 51-59 (1980-01-01)
The new non-steroidal antiinflammatory (NSAI)2 agent, piroxicam [4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide], is a highly active inhibitor of prostaglandin (PG) synthesis by methylcholanthrene transformed mouse fibroblasts (MC5-5) and rabbit synovial cells in culture. Comparison of the PG biosynthesis inhibitory activity of piroxicam with
Seung-Won Choi et al.
Plant biotechnology (Tokyo, Japan), 39(3), 323-327 (2022-11-10)
Agrobacterium-mediated transformation is a key innovation for plant breeding, and routinely used in basic researches and applied biology. However, the transformation efficiency is often the limiting factor of this technique. In this study, we discovered that oxicam-type nonsteroidal anti-inflammatory drugs
Wanwadee Luksurapan et al.
Archives of physical medicine and rehabilitation, 94(2), 250-255 (2012-10-16)
To compare the effects of phonophoresis of piroxicam (PhP) and ultrasound therapy (UT) in patients with mild to moderate, symptomatic knee osteoarthritis (OA). A randomized, double-blind, controlled trial. Department of rehabilitation medicine, university hospital. Patients with knee OA (N=46; mean
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