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NIST8671

NISTmAb, Humanized IgG1k Monoclonal Antibody

NIST® SRM® 8671

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About This Item

Kod UNSPSC:
41116107
NACRES:
NA.41

rodzaj przeciwciała

primary antibodies

klasa czystości

certified reference material

Postać

liquid

producent / nazwa handlowa

NIST®

metody

UV/Vis spectroscopy: suitable
liquid chromatography (LC): suitable
mass spectrometry (MS): suitable

format

matrix material

Opis ogólny

NISTmAb, Humanized IgG1k Monoclonal Antibody is a recombinant antibody expressed in murine suspension culture. It is a homodimer with two identical light chains and two identical heavy chains linked through inter- and intra- chain disulfide bonds with a molecular weight of 150 kDa. The protein possesses a low abundance of post-translational modifications including methionine oxidation, deamidation, and glycation. This humanized monoclonal antibody also has N-terminal pyroglutamination, C-terminal lysine clipping, and glycosylation of the heavy chains.

A unit of RM 8671 consists of one internal-threaded polypropylene cryovial containing 800 µL of 10 mg/mL NIST IgG1κ monoclonal antibody (NISTmAb) in 12.5 mmol/L L-histidine, 12.5 mmol/L L-histidine HCl (pH 6.0).

SRM 8671_Cert

SRM 8671_SDS

Zastosowanie

NISTmAb, Humanized IgG1k Monoclonal Antibody has been used as a standard for testing de novo sequencing algorithms on bottom-up mass spectrometry.This reference material (RM) is primarily intended for evaluating the performance of methods for determining physiochemical and biophysical attributes of monoclonal antibodies. It also provides a representative test molecule for developing novel technology in therapeutic protein characterization. Other potential uses include:
  • system suitability tests
  • establishing method or instrument performance and variability
  • comparing changing analytical test methods
  • assisting in method qualification

Komentarz do analizy

NIST8671 is intended for research use. It is not intended for animal or human consumption, clinical testing or therapeutic use.

Inne uwagi

  • RM 8671 is intended for research use.
  • Details on expiration, storage, safety, usage, and source are provided in the NIST certificate. 
  • Information on biomaterials, disposal, and transport is available in the SDS.

Informacje prawne

NIST is a registered trademark of National Institute of Standards and Technology
SRM is a registered trademark of National Institute of Standards and Technology
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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

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