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Dokumenty

T1126

Sigma-Aldrich

Thyroglobulin from porcine thyroid gland

powder

Synonim(y):

TG human

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Wszystkie zdjęcia(3)

About This Item

Numer CAS:
9010-34-8
Numer WE:
232-721-3
Numer MDL:
MFCD00132429
Kod UNSPSC:
12352202
NACRES:
NA.61

pochodzenie biologiczne

Porcine thyroid

Postać

powder

masa cząsteczkowa

~670 kDa

skład

Iodine, ≥0.3%

analiza azotu

14.0-17.5% total

metody

protein purification: suitable

popiół

≤4%

pI 

4.58

numer dostępu UniProt

F1RRV3

temp. przechowywania

−20°C

informacje o genach

pig ... TG(100156471)

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Działania biochem./fizjol.

Thyroglobulin has been shown to regulate the transcription of iodide porters including sodium iodide symporter and pendrin.
Thyroglobulin is a major protein involved with iodine metabolism. It consists of an iodine-containing protein that is stored in the thyroid gland and is converted into circulating thyroxines when the thyroid is stimulated by TSH (Thyroid Stimulating Hormone) from the pituitary. Thyroglobulin is often used as a carrier protein for the production of antibodies. Its advantage as a carrier protein comes from its large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Inne uwagi

Electrophoretically heterogeneous.

Uwaga dotycząca przygotowania

When reconstituted in water (20 mg/ml), a turbid solution with some insolubles is observed.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

L D Kohn et al.
Trends in endocrinology and metabolism: TEM, 12(1), 10-16 (2001-01-04)
Iodide transport by thyrocytes involves porters on the apical and basal surfaces of the cell facing the follicular lumen and bloodstream, respectively. Recent work identifies pendrin as an apical porter and shows that follicular thyroglobulin is a transcriptional regulator of
Antibody production and immunocytochemical localization of amino acid transporters.
David V Pow et al.
Methods in molecular biology (Clifton, N.J.), 227, 213-244 (2003-06-26)
Sanathana Konugolu Venkata Sekar et al.
Scientific reports, 8(1), 10015-10015 (2018-07-04)
Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin-key tissue constituents
C Nascimento et al.
European journal of endocrinology, 169(5), 689-693 (2013-08-14)
Thyroglobulin (Tg) measurement is a major tool for the follow-up of differentiated thyroid cancer (DTC) patients; however, in patients who do not undergo radioactive iodine (RAI) ablation, normal ultrasensitive Tg levels measured under levothyroxine treatment (usTg/l-T4) are not well defined.
Rodrigo Moreno-Reyes et al.
The Journal of clinical endocrinology and metabolism, 98(9), 3694-3701 (2013-07-13)
Many countries in Europe remain mildly iodine deficient but relatively few country-level data exist on mild iodine deficiency (MID) and its impact on thyroid function in pregnant women. To determine the prevalence of thyroid disorders in pregnant women in Belgium
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Produkty

A validated amino acid analysis assay for accurate quantification of stable isotope labeled protein reference materials: SIL thyroglobulin case study

With the emergence of mass spectrometry for the clinical measurement of proteins in biological matrices, the development of biological reference materials will continue to grow in importance.

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