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Kluczowe dokumenty
34007
Metronidazole-OH
VETRANAL®, analytical standard
Synonim(y):
1-(2-Hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole, Hydroxymetronidazole, MNZOH
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About This Item
Wzór empiryczny (zapis Hilla):
C6H9N3O4
Numer CAS:
Masa cząsteczkowa:
187.15
Numer MDL:
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
NACRES:
NA.24
Polecane produkty
klasa czystości
analytical standard
Poziom jakości
linia produktu
VETRANAL®
okres trwałości
limited shelf life, expiry date on the label
metody
HPLC: suitable
gas chromatography (GC): suitable
Zastosowanie
forensics and toxicology
pharmaceutical (small molecule)
Format
neat
ciąg SMILES
OCCn1c(CO)ncc1[N+]([O-])=O
InChI
1S/C6H9N3O4/c10-2-1-8-5(4-11)7-3-6(8)9(12)13/h3,10-11H,1-2,4H2
Klucz InChI
AEHPOYAOLCAMIU-UHFFFAOYSA-N
Opis ogólny
Metronidazole-OH is a genotoxic, carcinogenic and mutagenic drug, belonging to the class of nitroimidazoles, used as a broad spectrum veterinary drug for the treatment and prevention of certain bacterial and protozoal diseases in farm animals.
Zastosowanie
Metronidazole-OH may be used as a reference standard for the determination of the antibiotic, metronidazole-OH in water samples and meat matrices using ultra-high-performance liquid chromatography coupled to quadrupole-linear ion trap tandem mass spectrometry (UPLC-Qtrap-MS/MS) and ultra-performance liquid chromatography (UPLC) coupled to time of flight mass spectrometry (TOF).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Polecane produkty
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Informacje prawne
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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C S Easmon et al.
The British journal of venereal diseases, 58(4), 246-249 (1982-08-01)
The hydroxy metabolite of metronidazole was found to be more active against 21 strains of Gardnerella vaginalis than the parent compound and less affected by culture in carbon dioxide. After 400 mg oral metronidazole (Flagyl) plasma concentrations of the two
Quantitative multiresidue method for about 100 veterinary drugs in different meat matrices by sub 2-particulate high-performance liquid chromatography coupled to time of flight mass spectrometry.
Kaufmann A, et al.
Journal of Chromatography A, 1194(1), 66-79 (2008)
M N Muscará et al.
British journal of clinical pharmacology, 40(5), 477-480 (1995-11-01)
Metronidazole pharmacokinetics were studied in patients with different degrees of liver cirrhosis, classified according to the Child-Pugh algorithm (A, B or C, as liver disease severity increases) and in schistosomic patients. Metronidazole (500 mg) was administered i.v. as a slow
Fast and comprehensive multi-residue analysis of a broad range of human and veterinary pharmaceuticals and some of their metabolites in surface and treated waters by ultra-high-performance liquid chromatography coupled to quadrupole-linear ion trap tandem mass spectrometry.
Gros M, et al.
Journal of Chromatography A, 1248(6), 104-121 (2012)
S L Pendland et al.
Antimicrobial agents and chemotherapy, 38(9), 2106-2110 (1994-09-01)
Metronidazole is metabolized to two major oxidative products: an acid metabolite and a hydroxy metabolite. While the activity of the acid metabolite is negligible, the activity of the hydroxy metabolite is approximately 65% of the activity of the parent drug.
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