26454

Magnesium stearate

puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)

• Synonim(y): Stearic acid magnesium salt
• Wzór liniowy: [CH₃(CH₂)₁₆CO₂]₂Mg
• Numer CAS: 557-04-0
• Masa cząsteczkowa: 591.24
• Beilstein: 3919702
• Numer WE: 209-150-3
• Numer MDL: MFCD00036391
• Kod UNSPSC: 12352106
• Identyfikator substancji w PubChem: 57648176
• NACRES: NA.22

Właściwości

• klasa czystości: puriss.
• Próba: ≥40% stearic acid basis (GC); ≥90% stearic and palmitic acid basis; 4.0-5.0% Mg basis (calc on dry sub.)
• jakość: meets analytical specification of Ph. Eur., BP
• zanieczyszczenia: acidity or alkalinity, complies; microbiological impurity, in accordance; residual solvents, complies
• strata: ≤6.0% loss on drying, 105 °C
• mp: 200 °C (lit.)
• liczba kwasowa: 195‑210(fatty acid)
• rozpuszczalność: alcohol: insoluble; diethyl ether: insoluble; water: insoluble
• ślady anionów: chloride (Cl^-): ≤1000 mg/kg; sulfate (SO₄^2-): ≤5000 mg/kg
• ślady kationów: Cd: ≤3 mg/kg; Ni: ≤5 mg/kg; Pb: ≤10 mg/kg
• przydatność: in accordance for fatty acid composition; passes test for identity
• Zastosowanie: pharmaceutical (small molecule)
• ciąg SMILES: CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC
• InChI: 1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
• Klucz InChI: HQKMJHAJHXVSDF-UHFFFAOYSA-L

Opis

Zastosowanie

Magnesium stearate has been used as a tablet and capsule lubricant. It has also been used for preparing microcapsules.

Działania biochem./fizjol.

Magnesium stearate is the magnesium salt of stearic acid that possess lubricating properties and hence prevents ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets. Dry coating of drugs with magnesium stearate leads to flow improvement, flow-aid and lubrication effects, tabletability as well as non-inhibited dissolution rate.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): nwg
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Gloves