MABN624

Anti-Pan-QKI Antibody, clone N147/6

clone N147/6, from mouse

• Synonim(y): Protein quaking, Hqk, HqkI, QKI
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: mouse
• Poziom jakości: 100
• forma przeciwciała: purified immunoglobulin
• rodzaj przeciwciała: primary antibodies
• klon: N147/6, monoclonal
• reaktywność gatunkowa: mouse, rat, human
• metody: western blot: suitable
• izotyp: IgG2bκ
• numer dostępu NCBI: NP_006766
• numer dostępu UniProt: Q96PU8
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... QKI(9444)

Opis

Opis ogólny

QKI is also called Protein Quaking or HqkI. QKI is an RNA-binding protein that plays a central role in myelinization. QKI acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, and is itself, regulated by alternative splicing. QKI is expressed in the frontal cortex of brain, but is shown to be down-regulated in the brain of schizophrenic patients.

Specyficzność

This antibody demonstrates cross reactivity against QKI-6, QKI-7, and QKI-7b (Prof. J. Trimmer, University of California, Davis.).

Immunogen

Recombinant protein corresponding to human Pan-QKI.

Zastosowanie

Anti-Pan-QKI Antibody, clone N147/6 is a highly specific mouse monoclonal antibody & that targets QKI & has been tested in western blotting.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Pan-QKI in human frontal cortex.

Immunohistochemistry Analysis: A representative lot detected Pan-QKI in rat hippocampus tissue (Prof. J. Trimmer, University of California, Davis.).

Western Blotting Analysis: 2 µg/mL from a representative lot detected Pan-QKI in 10 µg of rat brain tissue.

Western Blotting Analysis: 2 µg/mL from a representative lot detected Pan-QKI in 10 µg of mouse brain membrane tissue.

Western Blotting Analysis: A representative lot detected Pan-QKI in RBM cell lysates and in COS cell lysates transfected with QKI-5, QKI-6, QKI-7, and QKI-7b (Prof. J. Trimmer, University of Califorina, Davis.).

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Jakość

Evaluated by Western Blotting in rat brain membrane tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected Pan-QKI in 10 µg of rat brain membrane tissue lysate.

Opis wartości docelowych

~36-40 kDa observed. Uniprot describes six isoforms observed between 35-38 kDa Uncharacterized band(s) may be observed in some cell lysates.

Postać fizyczna

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Komentarz do analizy

Control
Rat brain membrane tissue lysate.

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable