MABN356

Anti-FKBP4 Antibody, clone 2H9.1

clone 2H9.1, from mouse

• Synonim(y): Peptidyl-prolyl cis-trans isomerase FKBP4, PPIase FKBP4, 51 kDa FK506-binding protein, FKBP51, 52 kDa FK506-binding protein, 52 kDa FKBP, FKBP-52, 59 kDa immunophilin, p59, FK506-binding protein 4, FKBP-4, FKBP59, HSP-binding immunophilin, HBI, Immunophi
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: mouse
• Poziom jakości: 100
• forma przeciwciała: purified immunoglobulin
• rodzaj przeciwciała: primary antibodies
• klon: 2H9.1, monoclonal
• reaktywność gatunkowa: human
• metody: immunohistochemistry: suitable (paraffin); western blot: suitable
• izotyp: IgG1κ
• numer dostępu NCBI: NP_002005
• numer dostępu UniProt: Q02790
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... FKBP4(2288)

Opis

Opis ogólny

FKBP4, also known as Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4), or 51 kDa FK506-binding protein (FKBP51), 52 kDa FK506-binding protein (FKBP-52), or 59 kDa immunophilin (p59), or FK506-binding protein 4 (FKBP-4) or FKBP59 , or HSP-binding immunophilin (HBI), or Immunophilin FKBP52 Rotamase, and encoded by the gene FKBP4/FKBP62 is a chaperon type protein that is involved in protein folding and trafficking and the immunoregulation of cellular responses. FKBP4 is a member of the immunophilin family of proteins. FKBP4 forms a component of unligated steroid receptors complexes and helps in the cycling of the receptors between the cytoplasm and nuclear compartments. FKBP4 also plays a role in regulating neuronal growth cones via the regulations of TRPC1 channels, and FKBP4 modules microtubule dynamics by inhibiting MAPT/TAU in microtubule assembly. Finally, FKBP4 also influences the regulation and modulation oxidative stress in mitochondria. FKBP4 will localize to the cytoplasm, mitochondria or nucleus depending upon cellular situation and is widely expressed.

Immunogen

Epitope: C-terminus

GST-tagged recombinant protein corresponding to the C-terminus of human FKBP4.

Zastosowanie

Anti-FKBP4 Antibody, clone 2H9.1 is an antibody against FKBP4 for use in western blotting & IHC (Paraffin).

Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected FKBP4 in human testis and human cerebellum tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

Jakość

Evaluated by Western Blotting in T47D cell lysate.

Western Blotting Analysis: 0.25 µg/mL of this antibody detected FKBP4 in 10 µg of T47D cell lysate.

Opis wartości docelowych

~52 kDa observed

Postać fizyczna

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1