MABF231

Anti-IL1RL1, clone RMST2-2, Azide Free Antibody

clone RMST2-2, from rat

• Synonim(y): Interleukin-1 receptor-like 1, Lymphocyte antigen 84, Protein ST2, Protein T1
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rat
• Poziom jakości: 100
• forma przeciwciała: purified antibody
• klon: RMST2-2, monoclonal
• reaktywność gatunkowa: mouse
• metody: activity assay: suitable; flow cytometry: suitable
• izotyp: IgG2aκ
• numer dostępu NCBI: NP_001020773
• numer dostępu UniProt: P14719
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified

Opis

Opis ogólny

IL1RL1, or Interleukin-1 receptor-like 1 protein, which is also known as Lymphocyte antigen 84, Protein ST2, or Protein T1, and encoded by the gene IL1rL1/Ly84/St2/Ste2 is the receptor for IL-33 and its activation recruits MYD88, IRAK1, IRAK4 and TRAF6 transcription factors and promotes the activation of ERK1/MAPK14 and MAPK8. IL1RL1 also is involved in T-helper Cell activation and function. IL1RL1 is localized to the plasma membrane. IL1RL1 is expressed in hematopoietic tissues, macrophages, epithelial and fibroblast cells lines as well as important tissues such as heart and lung. IL1RL1 is a member of the Toll-like receptor superfamily and interestingly plays an important role not in inflammation but in cardiac protection. When IL-33 binds it elicits a cardioprotective signaling response in the tissue and thus helps protect the heart tissue during times of ischemia for instance. Defects in IL1RL1 have been linked to atopic dermatitis and asthma.

Immunogen

Mouse ST-2/IL1RL1.

Zastosowanie

Activity Assay Analysis: A representative lot from an independent laboratory induces IL-6 production in BMCC cells (Prof. Hisaya Akiba, Jutendo University).

Anti-IL1RL1 antibody, clone RMST2-2, Azide Free is an antibody against IL1RL1 for use in flow cytometry & activity assay.

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

Jakość

Evalauted by Flow Cytometry in ST2/L5178Y and L5178Y parent cells.

Flow Cytometry Analysis: 1 µg of this antibody detected IL1RL1 in 1X10E6 ST2/L5178Y cells.

Opis wartości docelowych

64 kDa calculated

Postać fizyczna

Format: Purified

PBS without preservatives.

Protein G Purified

Przechowywanie i stabilność

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable