MABF112

Anti-CD70 Antibody, clone TAN 1-7

clone TAN 1-7, from rat

• Synonim(y): CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rat
• Poziom jakości: 100
• forma przeciwciała: purified antibody
• rodzaj przeciwciała: primary antibodies
• klon: TAN 1-7, monoclonal
• reaktywność gatunkowa: mouse
• metody: flow cytometry: suitable; western blot: suitable
• izotyp: IgG2aκ
• numer dostępu NCBI: NP_035747
• numer dostępu UniProt: O55237
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: mouse ... Cd70(21948)

Opis

Opis ogólny

CD70 is an interesting membrane bound cellular factor that acts as a cytokine which binds the receptor CD27. Binding induces the proliferation and co-stimulation of T cells and enhances the generation of cytolytic T-cells. Thus, CD70 plays important roles in T cell adaptive T cell response as well as in innate immunity and is required for the proper activation of the anti-viral adaptive response. CD70 also serves as a regulatory role in early cytokine responses to pathogens through the maintenance of Treg cell survival and function. Recent research also indicates that CD70 expression could be important in autoimmune disease regulation and in treatment of autoimmune diseases such as rheumatoid arthritis. CD70 is expressed on T cells, splenocytes, and thymocytes and it belongs to the TNF family of cellular signaling proteins.

Immunogen

Epitope: Extracellular domain

Recombinant protein corresponding to the extracellular domain of mouse CD70.

Zastosowanie

Anti-CD70 Antibody, clone TAN 1-7 | MABF112 is an antibody against CD70 Antibody for use in Western Blotting, Flow Cytometry.

Flow Cytometry Analysis: 2 µg of this antibody detected CD70 in mouse bone marrow dendritic cells treated with 2000U/mL GM-CSF and 0.1 ug/mL of LPS.
Functional Blocking Analysis: A representative lot detected CD70 in splenic CD8a+ DCs (Arora, P., et al. (2014). Immunity. 40:105-116).

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

Jakość

Evaluated by Western Blotting in mouse spleen tissue lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected CD70 in 10 µg of mouse spleen tissue lysate.

Opis wartości docelowych

~27 kDa observed

Postać fizyczna

Format: Purified

Protein G Purified

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Inne uwagi

Concentration: Please refer to lot specific datasheet.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1