CH2900010

Calcium Folinate Hydrate amorphous / Leucovorin Calcium amorphous

USP, Ph. Eur.

• Synonim(y): Folinic acid calcium salt, Calcii Folinas, Calcium Folinate, Leucovorin Calcium, Calcium folinate
• Wzór empiryczny (zapis Hilla): C₂₀H₂₁CaN₇O₇
• Numer CAS: 1492-18-8
• Masa cząsteczkowa: 511.50
• Kod UNSPSC: 41116107

Właściwości

• pochodzenie biologiczne: synthetic
• Poziom jakości: 600
• klasa czystości: GMO free; GMP; Halal; Kosher
• agency: Ph. Eur.; USP
• Formularz: powder
• Zastosowanie: liquid formulation; pharmaceutical
• temp. przechowywania: 2-8°C
• InChI: 1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1
• Klucz InChI: KVUAALJSMIVURS-ZEDZUCNESA-L

Opis

Opis ogólny

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Zastosowanie

Calcium Folinate Hydrate amorphous has three main clinical applications:
1) First line treatment for colorectal cancer: In combination with the anticancer drug 5-fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy.
2) Treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis as a rescue therapy to reduce the toxic side effects of intermediate or high doses of methotrexate.
3) Treatment of anemia caused by folate deficiency.

Opakowanie

Customized packaging possible

Informacje prawne

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable