AB1286-I
Anti-Monocarboxylate Transporter 1 Antibody
from chicken, purified by affinity chromatography
Synonim(y):
Protein IGO1
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About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
chicken
Poziom jakości
forma przeciwciała
affinity purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
polyclonal
oczyszczone przez
affinity chromatography
reaktywność gatunkowa
rat
reaktywność gatunkowa (przewidywana na podstawie homologii)
mouse (immunogen homology)
metody
immunohistochemistry: suitable (paraffin)
western blot: suitable
izotyp
IgY
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
unmodified
Opis ogólny
Monocarboxylate Transporter 1 (MCT1), also known as Solute carrier family 16 member 1 (SLC16A1), catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Monocarboxylate Transporter 1 is located in the cell membrane, and is widely expressed in both normal and cancer cells. Monocarboxylate Transporter 1 is involved in symptomatic deficiency in lactate transport (SDLT).
Specyficzność
This antibody recognizes the C-terminus of Monocarboxylate Transporter 1.
Immunogen
Epitope: C-terminus
KLH-conjugated linear peptide corresponding to the C-terminus of rat Monocarboxylate Transporter 1.
Zastosowanie
Anti-Monocarboxylate Transporter 1 Antibody is a highly specific chicken polyclonal antibody, that targets MCT1 & has been tested in western blotting & IHC (Paraffin).
Immunohistochemistry Analysis: A 1:2,500 dilution from a representative lot detected rat skeletal muscle and rat renal cortex tissues.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Signaling Neuroscience
Signaling Neuroscience
Jakość
Evaluated by Western Blot in rat brain membrane tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected rat brain membrane tissue lysate in 10 µg of rat brain membrane tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected rat brain membrane tissue lysate in 10 µg of rat brain membrane tissue lysate.
Opis wartości docelowych
Bands are observed at ~44 kDa and ~55 kDa This protein has been observed at ~47 kDa (Sepponen, K., et al. (2003). Acta Physiol Scand. 177(1):79-86.). In addition this protein has been observed at ~55 kDa in certain cell lysates, except in the rumen where two distinct bands appear at ~47 kDa and ~55 kDa (Koho, N., et al. (2005). Comp Biochem Physiol A Mol Integr Physiol. 141(1):29-34.). It is also known to be glycosylated (Carpenter, L., et al. (1996). Biochim Biophys Acta. 1279(2):157-163).
Powiązanie
Replaces: AB1286
Postać fizyczna
Affinity purified
Purified chicken polyclonal IgY in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Przechowywanie i stabilność
Stable for 1 year at 2-8°C from date of receipt.
Komentarz do analizy
Control
Rat brain membrane tissue lysate
Rat brain membrane tissue lysate
Inne uwagi
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Nigel P Moore et al.
International journal of cell biology, 2016, 2084252-2084252 (2016-11-16)
The distribution of monocarboxylate transporter (MCT) isoforms 1 and 4, which mediate the plasmalemmal transport of l-lactic and pyruvic acids, has been identified in the placentae of rats and rabbits at different ages of gestation. Groups of three pregnant Sprague-Dawley
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