648313

TRIS Hydrochloride

ULTROL^® Grade, ≥99% (titration), useful in pH range 7.0-9.0

• Synonim(y): Trizma^® hydrochloride, tris(Hydroxymethyl)aminomethane, HCl, TRIS HCl, TRIS hydrochloride, Tris(hydroxymethyl)aminomethane hydrochloride, Tromethane hydrochloride
• Wzór liniowy: NH₂C(CH₂OH)₃ · HCl
• Numer CAS: 1185-53-1
• Masa cząsteczkowa: 157.60
• Beilstein: 3675235
• Numer MDL: MFCD00012590
• Kod UNSPSC: 12161705
• NACRES: NA.25

Właściwości

• Poziom jakości: 100
• Próba: ≥99% (titration)
• Formularz: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze
• kolor: white
• przydatny zakres pH: 7.0-9.0
• pKa (25°C): 8.1
• rozpuszczalność: water: 500 mg/mL
• ślady kationów: heavy metals: ≤5 ppm
• Warunki transportu: ambient
• temp. przechowywania: 15-25°C
• ciąg SMILES: Cl.NC(CO)(CO)CO
• InChI: 1S/C4H11NO3.ClH/c5-4(1-6,2-7)3-8;/h6-8H,1-3,5H2;1H
• Klucz InChI: QKNYBSVHEMOAJP-UHFFFAOYSA-N

Opis

Opis ogólny

Absorbance (1.0 M, H₂O, 260 nm):≤0.1.

Useful in the pH range of 7.0-9.0. Has a pK_a of 8.1 at 25°C.

Widely used as a biological buffer (absorbance: <0.1 at 260 nm, 1.0 M, H₂O). A 1.0 M solution in H₂O has a pH range of 3.5-5.0 and a pK_a of 8.3 at 20°C.

Zastosowanie

• Effect of Organic Solvents on the Activity, Stability and Secondary Structure of asclepain cI, Using FTIR and Molecular Dynamics Simulations.: This study uses Tris hydrochloride as a buffer to assess the stability and structural changes in the asclepain cI enzyme, providing insights into enzyme applications in industrial and medical biotechnology (Origone et al., 2024).


• Microencapsulation of Omeprazole by Lactobacillus acidophilus ATCC 4356 Surface Layer Protein and Evaluation of its Stability in Acidic Condition.: Research demonstrates the use of Tris hydrochloride buffer in stabilizing microencapsulated omeprazole, aimed at enhancing drug delivery in acidic environments (Mobarak Qamsari et al., 2020).

Ostrzeżenie

Toxicity: Standard Handling (A)

Inne uwagi

The pH values of all buffers are temperature and concentration dependent. For Tris buffers, pH increases about 0.03 unit per °C decrease in temperature, and decreases 0.03-0.05 unit per ten-fold dilution. For precise applications, use a carefully calibrated pH meter with a glass/calomel combination electrode.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany

ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable