582231

Tetanus Toxoid

from Clostridium tetani, , lyophilized, nontoxic antigenic agent, Calbiochem^®

• Synonim(y): TTx
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• product name: Tetanus Toxoid, Clostridium tetani, This tetanus toxoid is prepared by formaldehyde inactivation of tetanus toxin. It retains its antigenic character, but is essentially nontoxic as determined by an LD₅₀ in mice.
• Poziom jakości: 200
• Postać: lyophilized
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze
• Warunki transportu: ambient
• temp. przechowywania: 2-8°C

Opis

Opis ogólny

Tetanus Toxoid belongs to the vaccine class of medications. Useful for immunization against tetanus and wound prophylaxis. Non-toxic as determined by an LD50 assay in mice.

Zastosowanie

Tetanus Toxoid, Clostridium tetani has been used: as a positive-control antigen used to assess antibodies against different SARS-CoV-2 proteins and peptides in patients; to assess lymphocyte proliferation in rabbit PBMC cultures in response to recall antigen stimulation; a stimulus for PBMCs from chronic HBV carrier donors in a T cell proliferation assay

Działania biochem./fizjol.

Tetanus Toxoid acts against Clostridium tetani, a gram-positive bacillus that produces a neurotoxin called tetanospasmin. Tetanospasmin prevents the release of an inhibitory neurotransmitter and causes unopposed muscle contractions and spasms. Tetanus toxoid vaccine stimulates the immune system to respond to the vaccine’s antigens. The immune system’s T-lymphocytes (TH2 and B cells) secrete immunoglobulin against the antigen in the vaccine. This immunoglobulin helps to protect against future infections.

Cechy i korzyści

• Prepared by formaldehyde inactivation of tetanus toxin.
• Prepared by formaldehyde inactivation of tetanus toxin.
• Toxoid retains its antigenic character, but is essentially nontoxic as determined by an LD50 in mice.
• Cell permeable: no
• Product does not compete with ATP.
• Reversible: no

Ostrzeżenie

Toxicity: Standard Handling (A)

Postać fizyczna

Lyophilized from 100 mM histidine, 100 mM NaCl, 5% trehalose, pH 7.0.

Rekonstytucja

Reconstitute in 50 µl of sterile distilled H₂O

Inne uwagi

Wrenger, S., et al. 2000. J. Biol. Chem.275, 22180.
Habermann E. and Goretzki, K. 1985. In Monoclonal Antibodies Against Bacteria (Macario, A.J.L., and Conway de Macario, E. eds.) Academic Press, New York, p.191.
Kozbor, D. and Roder, J.C. 1981. J. Immunol.127, 1275.
Bizzini, B., et al. 1970. Eur. J. Biochem.17, 100.
Largier, J.F. and Joubert, F.J. 1956. Biochem. Biophys. Acta20, 407.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable