487910-M

(±)-S-Nitroso-N-acetylpenicillamine

Nitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC₅₀ = 130 nM).

• Synonim(y): (±)-S-Nitroso-N-acetylpenicillamine, SNAP
• Wzór empiryczny (zapis Hilla): C₇H₁₂N₂O₄S
• Numer CAS: 79032-48-7
• Masa cząsteczkowa: 220.25
• Kod UNSPSC: 12352116

Właściwości

• Poziom jakości: 100
• Próba: ≥95% (HPLC)
• Formularz: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• kolor: pale green
• rozpuszczalność: DMSO: 25 mg/mL; ethanol: 25 mg/mL; methanol: soluble
• temp. przechowywania: −20°C
• InChI: 1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12)
• Klucz InChI: ZIIQCSMRQKCOCT-UHFFFAOYSA-N

Opis

Opis ogólny

Nitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t_1/2 = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC₅₀ = 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.

Nitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC₅₀ = 130 nM). Markedly activates soluble guanylate cyclase. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.

Działania biochem./fizjol.

EC50 = 130 nM in relaxation of isolated bovine coronary artery rings

Primary Target
Nitric oxide donor

Ostrzeżenie

Toxicity: Irritant (B)

Rekonstytucja

SNAP evolves NO immediately upon solubilization; reconstitute just prior to use.

Inne uwagi

Nishio, E., et al. 1996. Biochem. Biophys. Res. Commun.221, 163.
Askew, S.C., et al. 1995. Bioorg. Med. Chem.3, 1.
Fehsel, K., et al. 1995. J. Immunol.155, 2858.
Gopalkrishna, R., et al. 1993. J. Biol. Chem.268, 27180.
Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther.248, 762.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable