437694

DL-α-Lipoic Acid, Dihydro-

An effective antioxidant.

• Synonim(y): DL-α-Lipoic Acid, Dihydro-, DHLA, Dihydrolipoic Acid, Thiocytic Acid, Dihydro-
• Wzór empiryczny (zapis Hilla): C₈H₁₆O₂S₂
• Numer CAS: 462-20-4
• Masa cząsteczkowa: 208.34
• Numer MDL: MFCD00166974
• Kod UNSPSC: 12352106
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥95% (TLC)
• Postać: liquid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• kolor: light yellow
• rozpuszczalność: ethanol: 50 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: 2-8°C
• InChI: 1S/C8H16O2S2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H,9,10)
• Klucz InChI: IZFHEQBZOYJLPK-UHFFFAOYSA-N

Opis

Opis ogólny

An effective antioxidant. Scavenges hypochlorous acid, peroxyl, superoxide, hydroxyl and nitric oxide radicals. Also exhibits prooxidant properties, as demonstrated by its ability to reduce iron ions and to generate reactive sulfur-containing radicals that can damage certain proteins, such as α₁-antiproteinase and creatine kinase. DHLA has recently been shown to inhibit apoptosis in rat thymocytes induced by methylprednisolone and etoposide.

An effective antioxidant. Scavenges hypochlorous acid, peroxyl, superoxide, hydroxyl, and nitric oxide radicals. Also exhibits prooxidant properties, as demonstrated by its ability to reduce iron ions and to generate reactive sulfur-containing radicals that can damage certain proteins, such as α₁-antiproteinase and creatine kinase. DHLA has recently been shown to inhibit apoptosis in rat thymocytes induced by methylprednisolone and etoposide.

Działania biochem./fizjol.

Cell permeable: no

Primary Target
Scavenges hypochlorous acid, peroxyl, superoxide, hydroxyl, and nitric oxide radicals

Product does not compete with ATP.

Reversible: no

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Irritant (B)

Inne uwagi

Packer, L., et al. 1997. Adv. Pharmacol. 38, 79.
Bustamante, J., et al. 1995. Free Radic. Biol. Med. 19, 339.
Scott, B.C., et al. 1994. Free Radic. Res. 20, 119.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS05,GHS07,GHS09
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302,H315,H317,H318,H411
• Zwroty wskazujące środki ostrożności: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1
• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): 348.1 °F - Cleveland open cup
• Temperatura zapłonu (°C): 175.6 °C - Cleveland open cup