260585

5′-Deoxy-5′-methylthioadenosine

≥98% (HPLC), solid, MTAP substrate, Calbiochem^®

• Synonim(y): 5′-Deoxy-5′-methylthioadenosine, MTA, MeSAdo
• Wzór empiryczny (zapis Hilla): C₁₁H₁₅N₅O₃S
• Numer CAS: 2457-80-9
• Masa cząsteczkowa: 297.33
• Kod UNSPSC: 12352208
• NACRES: NA.77

Właściwości

• Nazwa produktu: 5′-Deoxy-5′-methylthioadenosine, A cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP).
• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Formularz: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze
• kolor: white
• rozpuszczalność: DMF: 25 mg/mL; DMSO: soluble
• Warunki transportu: ambient
• temp. przechowywania: −20°C
• InChI: 1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)
• Klucz InChI: WUUGFSXJNOTRMR-UHFFFAOYSA-N

Opis

Opis ogólny

A cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). Potently inhibits the protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also inhibits FGF-2 receptor tyrosine kinase activity as well as the proliferation of human astrocytes and glioma cells.

A naturally occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). A cell-permeable, reversible, and ATP-competitive inhibitor of protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also acts as an inhibitor of NGF-induced tyrosine phosphorylation in PC12 cells and blocks FGF-2 receptor tyrosine kinase in astrocytes and glioma cells.

Działania biochem./fizjol.

Primary Target
protein carboxymethyltranferase

Secondary Target
FGF-2receptor tyrosine kinase activity

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Irritant (B)

Rekonstytucja

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.

Inne uwagi

Lee, S.H., and Cho, Y.D. 1998. Exp. Cell Res.240, 282.
Smalheiser, N.R. 1998. Brain Res. Dev. Brain Res.51, 53.
Joy, A., et al. 1997. Oncogene14, 171.
Riscoe, M.K., et al. 1984. Biochem. Pharmacol.33, 3639.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable