M6133

7-Methylguanosine 5′-triphosphate sodium salt

≥85% (HPLC)

• Synonim(y): m7GTP
• Wzór empiryczny (zapis Hilla): C₁₁H₁₈N₅O₁₄P₃ · xNa⁺
• Numer CAS: 104809-18-9
• Masa cząsteczkowa: 537.21 (free acid basis)
• Numer MDL: MFCD00063376
• Kod UNSPSC: 41106305
• Identyfikator substancji w PubChem: 24897079
• NACRES: NA.51

Właściwości

• pochodzenie biologiczne: natural (inorganic)
• Poziom jakości: 200
• Próba: ≥85% (HPLC)
• Postać: powder
• temp. przechowywania: −20°C
• ciąg SMILES: [Na+].C[n+]1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O)c3N=C(N)NC([O-])c13
• InChI: 1S/C11H20N5O14P3.Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22;/h3-4,6-7,9-10,17-18H,2H2,1H3,(H,23,24)(H,25,26)(H3,12,13,14)(H2,20,21,22);/q;+1/p-1/t4-,6-,7-,9?,10-;/m1./s1
• Klucz InChI: FSMRTZAMTMQMEF-OCMBMSOASA-M

Opis

Opis ogólny

7-Methylguanosine 5′-triphosphate is a mRNA cap structural analog.

Zastosowanie

7-Methylguanosine 5′-triphosphate (m7GTP) is use to study the structures and mechanisms of eukaryotic cellular mRNA caps in the context of mRNA involvement in protein synthesis. m7GTP may be used to create affinity media for capture and purification of molecules such as eukaryotic initiation factor eIF4E.

7-Methylguanosine 5′-triphosphate sodium salt has been used to test its affinity towards Poly(A)-specific ribonuclease (PARN) polypeptides using fluorescence titrations. It has also been used in crystallization along with gemin5 fragment (G5N) and DM15 region of human La-related 15 protein 1 ( LARP1).

Działania biochem./fizjol.

7-Methylguanosine 5′-triphosphate (m7GTP) inhibits in vitro protein synthesis by binding to translation initiation complexes. m7GTP is useful to study the structures and mechanisms of eukaryotic cellular mRNA caps in the context of mRNA involvement in protein synthesis. m7GTP has a high affinity for eukaryotic initiation factor eIF4E and may be used to create affinity media for their capture and purification.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H302
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Gloves