1.00590

Glycine

crystalline, EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• Synonim(y): Glycine, Gly, Aminoacetic acid, Aminoethanoic acid, Aminoacetic acid, Aminoethanoic acid, Glycocoll
• Wzór liniowy: NH₂CH₂COOH
• Numer CAS: 56-40-6
• Masa cząsteczkowa: 75.07
• Beilstein: 635782
• Numer MDL: MFCD00008131
• Kod UNSPSC: 12352121
• Numer indeksu EC: 200-272-2

Właściwości

• agency: BP; ChP; JP; Ph. Eur.; USP
• Poziom jakości: 500
• ciśnienie pary: 0.0000171 Pa ( 25 °C)
• opis: EMPROVE^® EXPERT Ph Eur,BP,JP,USP
• linia produktu: EMPROVE^® EXPERT
• Próba: 98.5-101.0% (calculated on dried substance, perchloric acid titration)
• Postać: crystalline; solid
• metody: inhibition assay: suitable
• pH: 5.9-6.4 (20 °C, 50 g/L in H₂O)
• pKa (25°C): (1) 2.35, (2) 9.60; 2.35
• mp: 240 °C (dec.) (lit.)
• rozpuszczalność: soluble 250 g/L
• gęstość: 1.161 g/cm³ at 20 °C
• Zastosowanie: liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• temp. przechowywania: 2-30°C
• ciąg SMILES: NCC(O)=O
• InChI: 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• Klucz InChI: DHMQDGOQFOQNFH-UHFFFAOYSA-N

Opis

Opis ogólny

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Zastosowanie

Glycine is an amino acid which is used widely in the biopharma industry as stabilizer, tonicity modifier, buffer and precipitating agent. It is also used as an emollient, emulsifying agent and solubilizer in solid and semi-solid formulations.
Due to its low microbial and endotoxin limits, Glycine cryst. Emprove^® Expert is especially suitable for high-risk applications.

Działania biochem./fizjol.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Informacje prawne

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

The substance 1.00590 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable