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06-284

Sigma-Aldrich

Anti-Nitrotyrosine Antibody

Upstate®, from rabbit

Synonim(y):

Anti-Nitrotyrosine, Detection Antibody, Nitrotyrosine Detection Antibody

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Wszystkie zdjęcia(6)

About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

pochodzenie biologiczne

rabbit

Poziom jakości

100

forma przeciwciała

affinity purified immunoglobulin

rodzaj przeciwciała

primary antibodies

klon

polyclonal

reaktywność gatunkowa (przewidywana na podstawie homologii)

all

producent / nazwa handlowa

Upstate®

metody

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

izotyp

IgG

Warunki transportu

dry ice

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... NOS1(4842)

Opis ogólny

Nitrotyrosine has been identified as an indicator of cell damage and inflammation, as well as of the production of NO. It is believed that measuring the concentration of nitrotyrosine will serve as a marker for damage caused by NO in the cell. Previous studies have shown that nitrotyrosine has been found in inflammatory conditions such as atherosclerotic plaques and rheumatoid arthritis, among others.

Specyficzność

Recognizes proteins which are nitrated.

Immunogen

Nitrated KLH

Zastosowanie

  • Immunocytochemistry Analysis: A 1:200 dilution from a representative lot detected in fixed and permeabilized A-431 cells treated with 5mM peroxynitrite for 15 minutes.
  • Immunohistochemistry Applications: A representative lot detected Nitrotyrosine in human colon cancer, human Alzheimer′s brain and human diabetic kidney tissue sections.
  • Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
Research Sub Category
Neurotransmitters & Receptors

Neurodegenerative Diseases
This rabbit polyclonal Anti-Nitrotyrosine, Cat. No. 06-284 is tested for use in Western Blotting, Immunohistochemistry and Immunocytochemistry, for the detection of Nitrotyrosine.

Jakość

routinely evaluated by immunoblot on nitrotyrosine immunoblotting controls (Catalog #12-354)

Opis wartości docelowych

Predicted MW for nitrated-BSA: 85 kDa

Postać fizyczna

Format: Purified
ImmunoAffinity Purified
Purified Rabbit IgG in buffer containing 0.1M Tris-Glycine, 0.15M NaCl, pH 7.4, 0.05% sodium azide, and 10 mg/mL BSA

Przechowywanie i stabilność

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Informacje prawne

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

A Perner et al.
Gut, 49(3), 387-394 (2001-08-21)
Luminal nitric oxide (NO) is greatly increased in the colon of patients with collagenous and ulcerative colitis. To define the source and consequence of enhanced NO production we have studied expression of NO synthase (NOS) isoforms and nitrotyrosine in mucosal
Reactive nitrogen species contribute to blood-labyrinth barrier disruption in suppurative labyrinthitis complicating experimental pneumococcal meningitis in the rat
Kastenbauer, S., et al
Brain Research, 904, 208-217 (2001)
Free 3-nitrotyrosine causes striatal neurodegeneration in vivo
Mihm, M. J., et al
The Journal of Neuroscience, 21, RC149-RC149 (2001)
T Akaike et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 14(10), 1447-1454 (2000-07-06)
Nitric oxide (NO), superoxide (O(2)(-)), and their reaction product peroxynitrite (ONOO(-)) are generated in excess during a host's response against viral infection, and contribute to viral pathogenesis by promoting oxidative stress and tissue injury. Here we demonstrate that NO and
Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin.
Kern, T S and Engerman, R L
Diabetes, 50, 1636-1642 (2001)
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Produkty

Acute and Chronic Inflammation: Microglia in Neuroprotection and Neurodegeneration

The term neurodegeneration characterizes a chronic loss of neuronal structure and function leading to progressive mental impairments.

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