N-903

Nordiazepam-d₅ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Wzór empiryczny (zapis Hilla): C₁₅D₅H₆ClN₂O
• Numer CAS: 65891-80-7
• Masa cząsteczkowa: 275.74
• Numer WE: 200-659-6
• Kod UNSPSC: 41116107
• NACRES: NA.24

Właściwości

• klasa czystości: certified reference material
• Postać: liquid
• Właściwości: Snap-N-Spike^®/Snap-N-Shoot^®
• opakowanie: ampule of 1 mL
• producent / nazwa handlowa: Cerilliant^®
• drug control: Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• stężenie: 100 μg/mL in methanol
• metody: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Zastosowanie: clinical testing
• format: single component solution
• temp. przechowywania: −20°C
• ciąg SMILES: [2H]c1c([2H])c([2H])c(c([2H])c1[2H])C2=NCC(=O)Nc3ccc(Cl)cc23
• InChI: 1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)/i1D,2D,3D,4D,5D
• Klucz InChI: AKPLHCDWDRPJGD-RALIUCGRSA-N

Opis

Opis ogólny

Nordiazepam is a benzodiazepine prescribed for treatment of anxiety and panic attacks. This stable-labeled internal standard is suited for quantitation of nordiazepam levels in urine, serum, or plasma by LC/MS or GC/MS for urine drug testing, clinical toxicology, forensic analysis or isotope dilution methods. Nordiazepam is also a primary urinary metabolite of benzodiazepines diazepam and chlrodiazepoxide.

Zastosowanie

• Validation in psychoactive drug detection: A study developed a rapid UPLC-MS/MS method to detect multiple psychoactive substances, including Nordiazepam-d5, in post-mortem whole blood samples, highlighting its utility in forensic toxicology and drug monitoring (Barone et al., 2023).
• Application in neonatal drug exposure studies: Research employed liquid chromatography-high-resolution mass spectrometry, utilizing Nordiazepam-d5 as a reference, to determine venlafaxine exposure during gestation through neonatal hair analysis, illustrating its value in pediatric forensic investigations (Favretto et al., 2010).
• Detection in hair samples: The use of Nordiazepam-d5 was explored in a French study for the identification of benzodiazepine consumption in hair samples from drug addicts, demonstrating its effectiveness as a stable isotope-labeled standard for chronic exposure analysis (Vayssette et al., 1996).
• GC/MS analysis for benzodiazepine metabolites: A method was developed to analyze common benzodiazepine metabolites, including Nordiazepam, in urine, showcasing the application of Nordiazepam-d5 in creating more reliable and reproducible results in toxicological testing (West and Ritz, 1993).

Informacje prawne

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02,GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H225,H301 + H311 + H331,H370
• Zwroty wskazujące środki ostrożności: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Klasyfikacja zagrożeń: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organy docelowe: Eyes,Central nervous system
• Kod klasy składowania: 3 - Flammable liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): 49.5 °F - closed cup
• Temperatura zapłonu (°C): 9.7 °C - closed cup