N-100

Norchlordiazepoxide solution

1.0 mg/mL (Acetonitrile:DMSO (80:20)(v/v)), ampule of 1 mL, certified reference material, Cerilliant^®

• Wzór empiryczny (zapis Hilla): C₁₅H₁₂ClN₃O
• Numer CAS: 7722-15-8
• Masa cząsteczkowa: 285.73
• Numer MDL: MFCD27976665
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329818475
• NACRES: NA.24

Właściwości

• klasa czystości: certified reference material
• Postać: liquid
• Właściwości: (Snap-N-Spike^®)
• opakowanie: ampule of 1 mL
• producent / nazwa handlowa: Cerilliant^®
• stężenie: 1.0 mg/mL (Acetonitrile:DMSO (80:20)(v/v))
• metody: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Zastosowanie: clinical testing
• format: single component solution
• temp. przechowywania: −20°C
• ciąg SMILES: ClC1=CC2=C(N=C(N)C[N+]([O-])=C2C3=CC=CC=C3)C=C1
• InChI: 1S/C15H12ClN3O/c16-11-6-7-13-12(8-11)15(10-4-2-1-3-5-10)19(20)9-14(17)18-13/h1-8H,9H2,(H2,17,18)
• Klucz InChI: LNLMGKOHYYEWMY-UHFFFAOYSA-N

Opis

Opis ogólny

Norchlordiazepoxide is a major urinary metabolite of the benzodiazepine chlordiazepoxide, indicated for short term treatment of severe anxiety and for the management of acute alcohol withdrawal syndrome. The metabolite, also known as N-desmethylchlordiazepoxide, is pharmacologically active. This Certified Spiking Solution^® is suitable for GC/MS or LC/MS methods in chlordiazepoxide testing for forensic analysis, urine drug testing, or clinical toxicology.

Zastosowanie

• Immunoassay detection of benzodiazepines: A study assessed the efficacy of immunoassays in detecting benzodiazepines and their metabolites in blood, including Norchlordiazepoxide. This research is vital for clinical toxicology and forensic applications, providing essential insights into drug monitoring and abuse detection (Huang & Moody, 1995).


• High-performance liquid chromatographic method: A method for determining clonazepam and other benzodiazepines in serum was developed, applicable to Norchlordiazepoxide. This technique underscores the compound′s clinical relevance and enhances pharmacokinetic and therapeutic drug monitoring (Haver et al., 1986).


• Photolytic derivatization for LCEC: Research highlighted the use of photolytic derivatization to improve the determinations of pharmaceuticals, including benzodiazepines like Norchlordiazepoxide, in biological fluids. This study contributes to the advancements in analytical chemistry, improving the accuracy of drug level assessments (Selavka et al., 1985).


• Postmortem stability of benzodiazepines: An investigation into the postmortem stability of benzodiazepines in blood and tissues provided critical data for forensic sciences, particularly regarding the stability of compounds like Norchlordiazepoxide after death, aiding in legal and medical examinations (Levine et al., 1983).

Informacje prawne

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02,GHS07
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H225,H302 + H312 + H332,H319
• Zwroty wskazujące środki ostrożności: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Kod klasy składowania: 3 - Flammable liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): 35.6 °F - closed cup
• Temperatura zapłonu (°C): 2.0 °C - closed cup