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860600P

Avanti

Lyso SM (d18:1)

Avanti Research™ - A Croda Brand 860600P, powder

Synonim(y):

Sphingosylphosphorylcholine

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About This Item

Wzór empiryczny (zapis Hilla):
C23H49N2O5P
Numer CAS:
1670-26-4
Masa cząsteczkowa:
464.62
Kod UNSPSC:
12352211
NACRES:
NA.25

Postać

powder

opakowanie

pkg of 1 × 10 mg (860600P-10mg)
pkg of 1 × 25 mg (860600P-25mg)
pkg of 1 × 5 mg (860600P-5mg)
pkg of 1 × 50 mg (860600P-50mg)

producent / nazwa handlowa

Avanti Research™ - A Croda Brand 860600P

typ lipidu

sphingolipids

Warunki transportu

dry ice

temp. przechowywania

−20°C

ciąg SMILES

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(N)COP([O-])(OCC[N+](C)(C)C)=O

InChI

1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m0/s1

Klucz InChI

JLVSPVFPBBFMBE-HXSWCURESA-N

Opis ogólny

Lyso SM (d18:1), also known as sphingosylphosphorylcholine (SPC), is a bioactive lipid molecule. This lysophospholipid is present in normal blood plasma, ascites and various tissues.

Zastosowanie

Lyso SM (d18:1) has been used:
  • to study its effect on the skeletal muscle ryanodine receptor (RyR1), in the presence and absence of calmodulin through single channel recordings in planar lipid bilayers
  • as an inhibitor of Ca2+ sensor calmodulin (CaM)
  • as a standard in circular dichroism (CD) spectroscopy to determine lipid selectivity of the lipid-peptide interactions

Działania biochem./fizjol.

Lyso SM (d18:1) or sphingosylphosphorylcholine (SPC) is a lipid mediator that exhibits second messenger functions. It regulates ryanodine receptors (RyRs) and releases Ca2+ from the sarco/endoplasmic reticulum. Lyso SM (d18:1) acts as an endogenous inhibitor of ubiquitous Ca2+ sensor calmodulin (CaM).

Opakowanie

5 mL Amber Glass Screw Cap Vial (860600P-10mg)
5 mL Amber Glass Screw Cap Vial (860600P-25mg)
5 mL Amber Glass Screw Cap Vial (860600P-50mg)
5 mL Amber Glass Screw Cap Vial (860600P-5mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Dagmar Meyer zu Heringdorf et al.
Biochimica et biophysica acta, 1582(1-3), 178-189 (2002-06-19)
Compared to the lysophospholipid mediators, sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), little information is available regarding the molecular mechanisms of action, metabolism and physiological significance of the related sphingosylphosphorylcholine (SPC). S1P and LPA have recently been established as agonists at
Erika Kovacs et al.
Biochemical and biophysical research communications, 401(2), 281-286 (2010-09-21)
Sphingosylphosphorylcholine (SPC), a lipid mediator with putative second messenger functions, has been reported to regulate ryanodine receptors (RyRs), Ca2+ channels of the sarco/endoplasmic reticulum. RyRs are also regulated by the ubiquitous Ca2+ sensor calmodulin (CaM), and we have previously shown
Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.
The Journal of biological chemistry, 280(52), 43280-43280 (2006-02-25)
Tomokazu Yasuda et al.
Langmuir : the ACS journal of surfaces and colloids, 34(44), 13426-13437 (2018-10-24)
In this study, we applied fluorescence spectroscopy, differential scanning calorimetry (DSC), and 2H NMR to elucidate the properties of nanoscopic segregated domains in stearoylsphingomyelin (SSM)/dioleoylphosphatidylcholine (DOPC) and dihydrostearoylsphingomyelin (dhSSM)/DOPC binary membranes. The results obtained from fluorescence measurements suggest the existence
Caius G Radu et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(1), 245-250 (2003-12-19)
G2A is an immunoregulatory G protein-coupled receptor predominantly expressed in lymphocytes and macrophages. Ectopic overexpression studies have implicated G2A as a receptor for the bioactive lysophospholipid, lysophosphatidylcholine (LPC). However, the functional consequences of LPC-G2A interaction at physiological levels of receptor
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