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860052P

Avanti

Ceramide (Brain)

Ceramide (Brain, Porcine), powder

Synonim(y):

C18 Ceramide; N-octadecanoyl-D-erythro-sphingosine; N-(octadecanoyl)-sphing-4-enine

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About This Item

Numer CAS:
497156-25-9
Kod UNSPSC:
12352211
NACRES:
NA.25

Próba

>99% (TLC)

Postać

powder

opakowanie

pkg of 1 × 200 mg (860052P-200mg)
pkg of 1 × 25 mg (860052P-25mg)

producent / nazwa handlowa

Avanti Research™ - A Croda Brand 860052P

typ lipidu

sphingolipids

Warunki transportu

dry ice

temp. przechowywania

−20°C

InChI

1S/C36H71NO3/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(40)37-34(33-38)35(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h29,31,34-35,38-39H,3-28,30,32-33H2,1-2H3,(H,37,40)/b31-29+/t34-,35+/m0/s1

Klucz InChI

VODZWWMEJITOND-NXCSZAMKSA-N

Opis ogólny

Ceramides comprise sphingoid base attached to fatty acyl chain by an amide bond. They vary in length, saturation and hydroxylation of the fatty acid chain and sphingoid base. Ceramides are synthesized by sphingomyelinase in salvage and de novo synthesis pathway. In brain, ceramide synthases mediate the synthesis of ceramides.

Zastosowanie

Ceramide (Brain) has been used as a lipid standard
  • in ultra performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry (UPLC-ESI-Q-TOF-MS)
  • in liquid chromatography with a hydrophilic interaction column
  • in liposome preparation to test it effect on human α–synuclein aggregation

Działania biochem./fizjol.

Ceramides are signaling molecules which play a key role in cellular events. Ceramides promote β-amyloid synthesis and induce neuronal death. Ceramide levels are associated with pathogenesis of many disease states. Impairment of ceramide metabolism is implicated in Parkinson′s and Alzheimer′s disease. High levels of ceramide is also associated with depression.

Opakowanie

5 mL Amber Glass Screw Cap Vial (860052P-200mg)
5 mL Amber Glass Screw Cap Vial (860052P-25mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

James P Madigan et al.
Experimental cell research, 388(2), 111860-111860 (2020-01-24)
There is growing evidence to support a role for the ceramide-metabolizing enzyme, glucosylceramide synthase (GCS), in resistance to a variety of chemotherapeutic agents. Whether GCS contributes to oxaliplatin resistance in colorectal cancer (CRC) has not yet been determined. We have
Ceramide and its related neurochemical networks as targets for some brain disorder therapies
Brodowicz J, et al.
Neurotoxicity Research, 33(2), 474-484 (2018)
Ceramide and Related-Sphingolipid Levels Are Not Altered in Disease-Associated Brain Regions of APPSL and APPSL/PS1M146L Mouse Models of Alzheimer's Disease: Relationship with the Lack of Neurodegeneration?
Barrier L, et al.
International Journal of Alzheimer's Disease, 2011 (2011)
Astrocytic ceramide as possible indicator of neuroinflammation
de Wit NM, et al.
Journal of Neuroinflammation, 16(1), 48-48 (2019)
Assessment of altered lipid homeostasis by HILIC-ion mobility-mass spectrometry-based lipidomics
Hines K M, et al.
Journal of Lipid Research, 58(4), 809-819 (2017)
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