QBD10011

Phthalimidooxy-dPEG^®₄-NHS ester

• Wzór empiryczny (zapis Hilla): C₂₃H₂₈N₂O₁₁
• Masa cząsteczkowa: 508.48
• Numer MDL: MFCD28155511
• Kod UNSPSC: 12352108
• Identyfikator substancji w PubChem: 329823874
• NACRES: NA.22

Właściwości

• Próba: >90%
• Postać: solid or viscous liquid
• przydatność reakcji: reactivity: amine reactive; reagent type: cross-linking reagent; reactivity: thiol reactive
• grupa funkcyjna: NHS ester
• architektura polimerowa: shape: linear; functionality: heterobifunctional
• Warunki transportu: ambient
• temp. przechowywania: −20°C
• ciąg SMILES: O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCON2C(C(C=CC=C3)=C3C2=O)=O

Opis

Cechy i korzyści

Phthalimidooxy-dPEG^®₄-NHS ester allows introduction of an oxyamine function onto a target molecule for cross-linking proteins or for creating stable conjugates with the target molecule. The oxyamine function is protected by a phthalimido protecting group on one end of the spacer arm, and the spacer is installed on the target molecule with the amine-reactive N-hydroxysuccinimide (NHS) group on the other end of the spacer. The single molecular weight dPEG^® spacers have precise length for spatial control. They are hydrophilic and non-immunogenic. The dPEG^® spacers improve water solubility and reduce aggregation and precipitation of proteins. The phthalimido protecting group can be removed using hydrazine. The oxyamine group exposed after deprotection can be reacted with an aldehyde- or ketone-containing molecule to form an oxime bond linking the two molecules. These reagents can be used with any protein, peptide, or small molecule that has a free amine.

Informacje prawne

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable