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719889

Sigma-Aldrich

Resomer® RG 502, Poly(D,L-Lactide-co-Glycolide)

lactide:glycolide 50:50, ester terminated, Mw 7,000-17,000

Synonim(y):

PLGA

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About This Item

Wzór liniowy:
[C3H4O2]x[C2H2O2]y
Kod UNSPSC:
12162002
NACRES:
NA.23

Postać

amorphous

proporcje

lactide:glycolide 50:50

masa cząsteczkowa

Mw 7,000-17,000

ramy czasowe degradacji

<3 months

lepkość

0.16-0.24 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

temp. przejścia

Tg 42-46 °C

Warunki transportu

wet ice

temp. przechowywania

2-8°C

Zastosowanie

Resomer® RG 502 can be used to formulate a PLGA-based nano drug delivery system for the anti-inflammatory drug, 6-bromoindirubin-3′-glycerol-oxime ether (6BIGOE).

Itcan also be used to prepare control release formulations for Naloxone HCldelivery.

Cechy i korzyści

  • Biocompatible
  • Biodegradable
  • Can be processed into almost any shape and size
  • Tunable mechanical properties

Informacje prawne

Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Yung-Hsin Cheng et al.
Experimental eye research, 179, 179-187 (2018-11-25)
Elevated intraocular pressure (IOP) in glaucoma is due to impairment of aqueous humor drainage via the uveoscleral or trabecular outflow pathway. Latanoprost reduces IOP by increasing the uveoscleral outflow. Despite its potency, long-term daily application of it may cause undesirable
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or
Vanna Sanna et al.
International journal of nanomedicine, 7, 5501-5516 (2012-10-25)
Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may
Mani Gajendiran et al.
Colloids and surfaces. B, Biointerfaces, 104, 107-115 (2013-01-10)
A series of biodegradable low molecular weight PLGA-PEG-PLGA tri-block copolymers have been synthesized in powder form. The anti-tuberculosis drug Isoniazid (INH) loaded polymeric core-shell nanoparticles (CSNPs) have been prepared by sonication followed by water-in-oil-in-water (w/o/w) double emulsification technique. The nanoparticles
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Poly(Glycerol Sebacate) in Tissue Engineering and Regenerative Medicine

The world of commercial biomaterials has stagnated over the past 30 years as few materials have successfully transitioned from the bench to clinical use. Synthetic aliphatic polyesters have continued to dominate the field of resorbable biomaterials due to their long history and track record of approval with the U.S. Food and Drug Administration (FDA).

Biodegradable Polyester-based Nanoparticle Formation by Miniemulsion Technique

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

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