49920

Glycerol formal

≥98.0% (GC)

• Synonim(y): 1,3(or 2,3)-O-Methylene-1,2,3-propanetriol
• Wzór empiryczny (zapis Hilla): C₄H₈O₃
• Numer CAS: 99569-11-6
• Masa cząsteczkowa: 104.10
• Beilstein: 103206
• Numer MDL: MFCD10039829
• Kod UNSPSC: 12352100
• Identyfikator substancji w PubChem: 57651229
• NACRES: NA.22

Właściwości

• Poziom jakości: 200
• Próba: ≥98.0% (GC)
• zawiera: ~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer
• skład: 5-hydroxy-1,3-dioxane, ~60% ; 4-hydroxymethyl-1,3-dioxolane, ~40%
• współczynnik refrakcji: n20/D 1.451 (lit.); n20/D 1.451
• bp: 192-193 °C (lit.)
• gęstość: 1.203 g/mL at 25 °C (lit.)
• grupa funkcyjna: ether; hydroxyl
• ciąg SMILES: OCC1COCO1.OC2COCOC2
• InChI: 1S/2C4H8O3/c5-4-1-6-3-7-2-4;5-1-4-2-6-3-7-4/h2*4-5H,1-3H2
• Klucz InChI: JIUMSISXCKWZTA-UHFFFAOYSA-N

Opis

Opis ogólny

Glycerol formal (GF) is a light glycerol acetal that is composed of ~60% 5-hydroxy-1,3-dioxane and ~40% 4-hydroxymethyl-1,3-dioxolane. It can be prepared by reacting glycerol and formaldehyde in the presence of acid catalyst. The potential of GF as an injection solvent for use in toxicity testing has been reported.

Zastosowanie

Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery

Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery. Glycerol formal was used as a vehicle for antibiotic delivery in rats.

Glycerol formal may be used in the multi-step synthesis of 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine), an analog of acyclovir. It may be used in the preparation of 4-substituted dioxolanes.

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