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Kluczowe dokumenty
390585
Suberohydroxamic acid
95%
Synonim(y):
N,N′-Dihydroxyoctanediamide, SBHA, Suberoyl bis-hydroxamic acid
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About This Item
Wzór liniowy:
[-(CH2)3CONHOH]2
Numer CAS:
Masa cząsteczkowa:
204.22
Numer MDL:
Kod UNSPSC:
12352100
Identyfikator substancji w PubChem:
NACRES:
NA.22
Polecane produkty
Próba
95%
mp
153-155 °C (lit.)
grupa funkcyjna
amine
ciąg SMILES
ONC(=O)CCCCCCC(=O)NO
InChI
1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)
Klucz InChI
IDQPVOFTURLJPT-UHFFFAOYSA-N
Działania biochem./fizjol.
HDAC inhibitor
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.
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produkt powiązany
Numer produktu
Opis
Cennik
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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