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Merck

ESR2

estrogen receptor 2 (ER beta)

Synonimy:
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(2100) Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13983) estrogen receptor 2 (beta)
  • Rat(25149) estrogen receptor 2 (ER beta)
  • chicken(395575) estrogen receptor 2 (ER beta)
  • dog(403639) estrogen receptor 2 (ER beta)
  • Horse(100033964) estrogen receptor 2 (ER beta)
  • cow(281146) estrogen receptor 2 (ER beta)
  • domestic cat(101086317) estrogen receptor 2 (ER beta)
  • domestic guinea pig(100731304) estrogen receptor 2 (ER beta)
  • Goat(100860823) estrogen receptor 2 (ER beta)
  • Domestic Rabbit(100346748) estrogen receptor 2 (ER beta)
  • sheep(443066) estrogen receptor 2 (ER beta)

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Small Molecule - Activator

Product Number
Opis
Gatunek
β-Nicotinamide adenine dinucleotide hydrate, ≥95% (HPLC),
Gatunek
human
β-Nicotinamide adenine dinucleotide lithium salt from Saccharomyces cerevisiae, ≥95%,
Gatunek
human
β-Nicotinamide adenine dinucleotide hydrate, ≥98%, BioUltra, from yeast,
Gatunek
human
β-Nicotinamide adenine dinucleotide hydrate, ≥99%,
Gatunek
human
β-Nicotinamide adenine dinucleotide hydrate, suitable for cell culture, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast,
Gatunek
human

Small Molecule - Agonist

Product Number
Opis
Gatunek
ERB-041, ≥98% (HPLC),
Gatunek
human
17α-Ethynylestradiol 3-cyclopentyl ether, ,
Gatunek
human
Estrone, ≥99%,
Gatunek
human, mouse, rat

Small Molecule - Allosteric Modulator

Product Number
Opis
Gatunek
Raloxifene hydrochloride for peak identification, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human
Raloxifene Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Gatunek
human
Raloxifene hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Gatunek
human
Raloxifene hydrochloride, solid,
Gatunek
human
Raloxifene hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human

Small Molecule - Antagonist

Product Number
Opis
Gatunek
2-Methoxyestradiol, powder,
Gatunek
human
Fulvestrant, >98% (HPLC),
Gatunek
human
Fulvestrant, United States Pharmacopeia (USP) Reference Standard,
Gatunek
human
Fulvestrant for system suitability, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human
Fulvestrant, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human

Antibodies

Product Number
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-ESR2 antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
bovine, human, mouse, pig, rat
Zastosowanie
western blot
Monoclonal Anti-ESR2 antibody produced in mouse, ,
Reaktywność gatunkowa
human, monkey, mouse
Zastosowanie
ChIP
dot blot

flow cytometry

immunocytochemistry

immunofluorescence

immunohistochemistry

western blot
Anti-phospho-Estrogen Receptor-? (pSer87) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunohistochemistry
Anty-fosfo-EstrogenReceptor-β (pSer105), affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
western blot
Przeciwciało anty-Esr2 wytwarzane u królików, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
western blot

Cell Lines

Product Number
Opis
Gatunek
MCF10A CELLS ESR2 (-/-), ,
Gatunek
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Opis
Gatunek
α-Estradiol, powder, ≥98% (TLC),
Gatunek
human, rat
Estradiol, meets USP testing specifications,
Gatunek
human, mouse, rat
β-Estradiol, ≥98%,
Gatunek
human, mouse, rat
β-Estradiol, analytical standard,
Gatunek
human, mouse, rat
Progesterone-Water Soluble, powder, BioReagent, suitable for cell culture,
Gatunek
mouse, human, rat

esiRNA

Product Number
Opis
Gatunek
MISSION® esiRNA, targeting human ESR2,
Gatunek
human