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Merck

ESR1

estrogen receptor 1

Synonimy:
ER, ESR, ESRA, ESTRR, Era, NR3A1
Gatunek:
Human ESR1 (2099), Mouse Esr1 (13982), Rat Esr1 (24890), Goat ESR1 (100860768), sheep ESR1 (443228), domestic guinea pig Esr1 (100713276), Zebrafish esr1 (259252), dog ESR1 (403640), cow ESR1 (407238), Horse ESR1 (791249) ...Więcej
Identyfikator UniProtKB:
P03372, Q13511, Q14276, Q5T5H7, Q6MZQ9, Q9NU51, Q9UDZ7, Q9UIS7
Identyfikator genu:
  • Human(2099) Summary: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008]
  • Mouse(13982) estrogen receptor 1 (alpha)
  • Rat(24890) estrogen receptor 1
  • Goat(100860768) estrogen receptor 1
  • sheep(443228) estrogen receptor 1
  • domestic guinea pig(100713276) estrogen receptor 1
  • Zebrafish(259252) estrogen receptor 1
  • dog(403640) estrogen receptor 1
  • cow(407238) estrogen receptor 1
  • Horse(791249) estrogen receptor 1
  • domestic cat(552888) estrogen receptor 1
  • chicken(396099) estrogen receptor 1
  • Thale Cress(837856) ethylene-responsive transcription factor ESR1

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Small Molecule - Activator

Numer produktu
Opis
Gatunek
131083
4-Phenylazophenol, 98%,
Gatunek
human
S4808
cis-Stilbene, 96%,
Gatunek
human, rat
N0632
β-Nicotinamide adenine dinucleotide sodium salt, ,
Gatunek
human
262013
trans-4-Stilbenemethanol, ,
Gatunek
human, rat
N7004
β-Nicotinamide adenine dinucleotide hydrate, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast,
Gatunek
human

Small Molecule - Agonist

Numer produktu
Opis
Gatunek
1255001
Estron, United States Pharmacopeia (USP) Reference Standard,
Gatunek
human
E1900000
Ethinylestradiol, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human
BP860
Estrone, British Pharmacopoeia (BP) Reference Standard,
Gatunek
human
1394008
Mestranol, United States Pharmacopeia (USP) Reference Standard,
Gatunek
human
1195001
Diethylstilbestrol, United States Pharmacopeia (USP) Reference Standard,
Gatunek
human

Small Molecule - Allosteric Modulator

Numer produktu
Opis
Gatunek
T0015000
Tamoxifen citrate for performance test, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human
1643306
Cytrynian tamoksyfenu, United States Pharmacopeia (USP) Reference Standard,
Gatunek
human
85256
Tamoxifen, analytical standard,
Gatunek
human
06734
Tamoxifen, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland,
Gatunek
human
T0014000
Tamoxifen citrate, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human

Small Molecule - Antagonist

Numer produktu
Opis
Gatunek
442858
4-tert-Octylphenol, analytical standard,
Gatunek
mouse
308501
Benzyl butyl phthalate, 98%,
Gatunek
mouse
524980
Dibutyl phthalate, 99%,
Gatunek
mouse
290823
4-tert-Octylphenol, 97%,
Gatunek
mouse
C33301
2-Chloro-4,6-diamino-1,3,5-triazine, 95%,
Gatunek
mouse

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
SAB4504399
Anti-phospho-Estrogen Receptor-α (pSer118) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunohistochemistry
western blot
SAB5600097
Anti-ER alpha antibody, Rabbit Monoclonal, recombinant, expressed in HEK 293 cells, clone RM292, purified immunoglobulin,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
17-603
ChIPAb+ Receptor estrogenowy α - przeciwciało i zestaw primerów zweryfikowane pod kątem ChIP, ascites fluid, from mouse,
Reaktywność gatunkowa
human, mouse
Zastosowanie
ChIP
western blot
07-662
Przeciwciało przeciwko receptorowi α związanemu z estrogenami, Upstate®, from rabbit,
Reaktywność gatunkowa
hamster, human, mouse, rat
Zastosowanie
electrophoretic mobility shift assay
immunohistochemistry
immunoprecipitation (IP)
western blot
SAB4301359
Anty-fosfo-EstrogenReceptor-α (pSer102), affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunohistochemistry
western blot

Small Molecule - Inhibitor

Numer produktu
Opis
Gatunek
D79403
Bicyclohexyl, 99%,
Gatunek
human
B34656
Biphenyl, ReagentPlus®, 99.5%,
Gatunek
human
W312908
Biphenyl, ≥99%,
Gatunek
human
374784
4′-Hydroxy-4-biphenylcarbonitrile, 97%,
Gatunek
human
168734
4,4′-Dihydroxybiphenyl, 97%,
Gatunek
human

Small Molecule - Ligand

Numer produktu
Opis
Gatunek
46665
Progesterone, VETRANAL®, analytical standard,
Gatunek
human
H4637
4-Hydroxyestradiol, ,
Gatunek
rat, human
T5648
Tamoxifen, ≥99%,
Gatunek
human, rat
P8783
Progesterone, powder, BioReagent, suitable for cell culture,
Gatunek
mouse, human, rat
P3972
Progesterone, meets USP testing specifications,
Gatunek
mouse, human, rat

Small Molecule - Mixed Agonist/Antagonist

Numer produktu
Opis
Gatunek
E8750
α-Estradiol, powder, ≥98% (TLC),
Gatunek
human, rat
M1629
Medroxyprogesterone 17-acetate, ≥97% (HPLC),
Gatunek
human, rat
E1024
Estradiol, meets USP testing specifications,
Gatunek
human, mouse, rat
E2257
β-Estradiol, powder, γ-irradiated, suitable for cell culture,
Gatunek
human, mouse, rat
E1132
β-Estradiol, analytical standard,
Gatunek
human, mouse, rat

Proteins

Numer produktu
Opis
Gatunek
E1528
Estrogen Receptor-α human, ≥80% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution,
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
EHU141651
MISSION® esiRNA, targeting human ESR1,
Gatunek
human