C2389

Cerulenin

from Cephalosporium caerulens, ≥98% (HPLC), powder, de novo phospholipid synthesis inhibitor

• 동의어(들): Helicocerin, (2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide
• 실험식(Hill 표기법): C₁₂H₁₇NO₃
• CAS Number: 17397-89-6
• Molecular Weight: 223.27
• Beilstein: 4140423
• EC Number: 241-424-8
• MDL number: MFCD00083595
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24892323
• NACRES: NA.77

속성

• product name: Cerulenin, ≥98% (HPLC), from Cephalosporium caerulens
• 생물학적 소스: Cephalosporium caerulens
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 형태: powder
• mp: 93 °C
• solubility: acetone: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to yellow
• 항생제 활성 스펙트럼: fungi
• 동작 모드: enzyme | inhibits
• 저장 온도: −20°C
• SMILES string: C/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O
• InChI: 1S/C13H18O3/c1-3-4-5-6-7-8-9-11(15)13-12(16-13)10(2)14/h3-4,6-7,12-13H,5,8-9H2,1-2H3/b4-3+,7-6+/t12-,13+/m0/s1
• InChI key: PTNNGEBMCNMENY-JIVMHGEESA-N
• 유전자 정보: human ... FASN(2194)

설명

일반 설명

Cerulenin, an inhibitor of de novo phospholipid synthesis triggers apoptosis in various wild type p53 and mutant p53 tumor cell lines. This fungal antibiotic also blocks the condensing enzyme involved in fatty acid and polyketide biosynthesis.

애플리케이션

Cerulenin has been used:

• as a fatty acid synthase inhibitor to study its effects on aldosterone-induced trained immunity
• as a blocker of fatty acid synthase to study its effects on the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)
• as a supplement in yeast extract–peptone–dextrose/glycerol (YPD/G) agar plates for the isolation of cerulenin-resistant yeast strains

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves