219557

Cerulenin, Cephalosporium caerulens

An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis.

• 동의어(들): Cerulenin, Cephalosporium caerulens
• 실험식(Hill 표기법): C₁₂H₁₇NO₃
• CAS Number: 17397-89-6
• Molecular Weight: 223.27
• MDL number: MFCD00083595
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (TLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white to off-white
• solubility: DMSO: 10 mg/mL; ethanol: 5 mg/mL; acetone: soluble
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C12H17NO3/c1-2-3-4-5-6-7-8-9(14)10-11(16-10)12(13)15/h2-3,5-6,10-11H,4,7-8H2,1H3,(H2,13,15)/b3-2+,6-5+/t10-,11-/m1/s1
• InChI key: GVEZIHKRYBHEFX-NQQPLRFYSA-N

설명

일반 설명

An anti-fungal antibiotic that inhibits fatty acid biosynthesis by binding, in equimolar ratio, to β-keto-acyl-ACP synthase. Also inhibits sterol synthesis by blocking the activity of HMG-CoA synthetase activity. Systemic and intracerebroventricular of this compound reduces feeding and induces weight loss.

An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. Also shown to inhibit feeding and induce dramatic weight loss in mice.

생화학적/생리학적 작용

Primary Target
sterol & fatty acid biosynthesis

포장

Packaged under inert gas

경고

Toxicity: Harmful (C)

기타 정보

Loftus, T.M., et al. 2000. Science288, 2379.
Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable