160210

4-Nitrophenyl chloroformate

96%, for peptide synthesis

• 동의어(들): Chloroformic acid 4-nitrophenyl ester
• Linear Formula: ClCO₂C₆H₄NO₂
• CAS Number: 7693-46-1
• Molecular Weight: 201.56
• Beilstein: 518127
• EC Number: 231-706-9
• MDL number: MFCD00007321
• UNSPSC 코드: 12352108
• PubChem Substance ID: 24849861
• NACRES: NA.22

속성

• 제품명: 4-Nitrophenyl chloroformate, 96%
• Quality Level: 200
• 분석: 96%
• 양식: powder
• 반응 적합성: reaction type: Carbonylations
• bp: 159-162 °C/19 mmHg (lit.)
• mp: 77-79 °C (lit.)
• 응용 분야: peptide synthesis
• 저장 온도: 2-8°C
• SMILES string: [O-][N+](=O)c1ccc(OC(Cl)=O)cc1
• InChI: 1S/C7H4ClNO4/c8-7(10)13-6-3-1-5(2-4-6)9(11)12/h1-4H
• InChI key: NXLNNXIXOYSCMB-UHFFFAOYSA-N

설명

일반 설명

4-Nitrophenyl chloroformate, also known as p-nitrophenyl chloroformate, is a coupling agent used in the synthesis of ureas, carbamates, and carbonates. It is also used as a building block in solid-phase peptide synthesis (SPPS) to obtain altered side chain functionalities in peptides.

애플리케이션

4-Nitrophenyl chloroformate is used as:

• A coupling agent to link the drug molecule with the polyrotaxane carrier molecule
• As an activated ester reagent that enables the covalent coupling of a peptide onto a macromer, such as oligo(poly(ethylene glycol) fumarate) (OPF)

안전성 정보

• 픽토그램: GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H314,H335
• 예방조치 성명서: P260 - P271 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point (°F): >230.0 °F
• Flash Point (°C): > 110 °C
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges