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A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.

A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.

Organic letters (2014-06-17)

Xiaowen Xu, Min Zhang, Huanfeng Jiang, Jia Zheng, Yiqun Li

要旨

A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare with the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents, making it a highly practical approach to access various 2,4-disubstituted-1,3,5-triazines.

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製品番号

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製品内容

Sigma-Aldrich

N,N-ジメチルホルムアミド, ACS reagent, ≥99.8%

Sigma-Aldrich

N,N-ジメチルホルムアミド, suitable for HPLC, ≥99.9%

Sigma-Aldrich

N,N-ジメチルホルムアミド, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.8% (GC)

Sigma-Aldrich

N,N-ジメチルホルムアミド, ReagentPlus^®, ≥99%

Sigma-Aldrich

N,N-ジメチルホルムアミド, for molecular biology, ≥99%

Sigma-Aldrich

N,N-ジメチルホルムアミド, biotech. grade, ≥99.9%

Sigma-Aldrich

銅, powder, 99.999% trace metals basis

Sigma-Aldrich

銅, foil, thickness 0.25 mm, 99.98% trace metals basis

Sigma-Aldrich

銅, powder, <425 μm, 99.5% trace metals basis

Sigma-Aldrich

銅, wire, diam. 1.0 mm, ≥99.9%

Sigma-Aldrich

N,N-ジメチルホルムアミド, anhydrous, 99.8%

Sigma-Aldrich

N,N-ジメチルホルムアミド, SAJ first grade, ≥99.0%

Sigma-Aldrich

銅, powder, <75 μm, 99%

Sigma-Aldrich

銅, nanopowder, 40-60 nm particle size (SAXS), ≥99.5% trace metals basis

Sigma-Aldrich

銅, powder (spheroidal), 10-25 μm, 98%

Sigma-Aldrich

N,N-ジメチルホルムアミド, JIS special grade, ≥99.5%

Sigma-Aldrich

銅, wire, diam. 0.25 mm, 99.999% trace metals basis

Sigma-Aldrich

銅, foil, thickness 0.025 mm, 99.98% trace metals basis

Sigma-Aldrich

銅, nanopowder, 60-80 nm particle size (SAXS), ≥99.5% trace metals basis

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銅, turnings, purum p.a., ≥99.0%

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銅, foil, ≥99.8% (complexometric)

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銅, powder (dendritic), <45 μm, 99.7% trace metals basis

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銅, wire, diam. 0.64 mm, 99.995% trace metals basis

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銅, foil, thickness 0.5 mm, 99.98% trace metals basis

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銅, shot, −3-+14 mesh, 99%

Sigma-Aldrich

銅, foil, thickness 1.0 mm, 99.999% trace metals basis

銅, mesh, 100x100mm, nominal aperture 0.14mm, thickness 0.25mm, wire diameter 0.115mm, 100x100 wires/inch, open area 30.3%, plain weave mesh

銅, rod, 100mm, diameter 9.5mm, hard, 99.9%

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銅, beads, 2-8 mm, 99.9995% trace metals basis

Sigma-Aldrich

銅, wire, diam. 2.0 mm, 99.999% trace metals basis