Z101

ジメリジン 二塩酸塩

solid

• 別名: (Z)-3-(4-ブロモフェニル)-N,N-ジメチル-3-(3-ピリジニル)-2-プロペン-1-アミン 二塩酸塩
• 実験式（ヒル表記法）: C₁₆H₁₇BrN₂ · 2HCl
• CAS番号: 61129-30-4
• 分子量: 390.15
• MDL番号: MFCD00069358
• UNSPSCコード: 12352200
• PubChem Substance ID: 24278138
• NACRES: NA.77

特性

• 形状: solid
• 色: white
• 溶解性: 0.1 M HCl: 45 mg/mL; H₂O: 66 mg/mL
• オーガナイザー: AstraZeneca
• SMILES記法: Cl[H].Cl[H].[H]\C(CN(C)C)=C(/c1ccc(Br)cc1)c2cccnc2
• InChI: 1S/C16H17BrN2.2ClH/c1-19(2)11-9-16(14-4-3-10-18-12-14)13-5-7-15(17)8-6-13;;/h3-10,12H,11H2,1-2H3;2*1H/b16-9-;;
• InChI Key: CXGURXWCQYHDIR-ULPVBNQHSA-N
• 遺伝子情報: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)

詳細

アプリケーション

Zimelidine dihydrochloride has been used as a serotonin transport inhibitor to study its inhibitory role in the uptake of exogenous serotonin by bipolar cells.

生物化学的／生理学的作用

Zimelidine, an antidepressant, is a specific 5-hydroxytryptamine (5-HT) reuptake inhibitor, that can be used in treating phobic anxiety. It is very effective and can be tolerated well in elderly individuals. This serotonin transport inhibitor is less likely than other antidepressants to have cardiovascular side effects. Unlike other tricyclic antidepressants, Zimelidine might promote weight loss but not weight gain.

特徴および利点

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法的情報

Astra AB社の許諾を得て販売しています。

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves