SRP6282

Nicotinamide N-Methyltransferase (hNNMT) human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

• 別名: NNMT
• UNSPSCコード: 12352204
• NACRES: NA.32

特性

• 由来生物: human
• リコンビナント: expressed in E. coli
• アッセイ: ≥98% (SDS-PAGE)
• 形状: liquid
• 分子量: 31.7 kDa (263 aa + NT 6xHis-tag)
• 包装: pkg of 1 mg; pkg of 100 μg; pkg of 20 μg
• 濃度: 3.42 mg/mL
• UniProtアクセッション番号: P40261
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... NNMT(4837)

詳細

詳細

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in caner diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer. The recombinant protein includes hNNMT with N-terminal His-tag.

物理的形状

3.42 mg/mL solution in 25 mM Tris (pH8.0) buffer containing 20% glycerol.

安全性情報

• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable