SRP6147

Ubiquitin Activating Enzyme E1 human

≥95% (SDS-PAGE)

• 別名: AMCX1, POC20, UBA1, UBE1, Ubiquitin E1
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 由来生物: human
• アッセイ: ≥95% (SDS-PAGE)
• 形状: liquid
• 有効性: >3 nM
• 分子量: 118
• 包装: pkg of 50 μg
• NCBIアクセッション番号: P22314
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... UBA1(7317)

詳細

詳細

Research area: Cell Signaling

Ubiquitin activating enzyme 1 (UBA1) or UBE1, is an ubiquitin-activating enzyme. The gene encoding it is localized on human chromosome Xp11.23.

アプリケーション

Ubiquitin Activating Enzyme E1 human has been used in in vitro and in vivo ubiquitination assays.

生物化学的／生理学的作用

Ubiquitin activating enzyme 1 (UBA1) has a role in cellular protein homeostasis. It is the first enzyme utilized in the pathway to conjugate ubiquitin onto target substrates through an ubiquitin-protein isopeptide bond. The C-terminal glycine of an ubiquitin (G76) is initially adenylated in an ATP dependent manner activating it so it can be transferred to the active site cysteine of UBE1 forming an ubiquitin-UBE1 thiolester. With the help of the other enzymes in the ubiquitin conjugation pathway (E2/E3 enzymes) the ubiquitin is transferred to a specific lysine on a target substrate. The protein has been associated with spinal muscular atrophy (SMA) and Huntington′s disease (HD).

物理的形状

In 50 mM Tris (pH 8.0), 100 mM NaCl and 10% glycerol.

調製ノート

バイアルは、開封前に遠心してください。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable