SRP0570

5′-NUCLEOTIDASE/CD73, His-Tag

recombinant, expressed in HEK 293 cells

• 別名: 5′- nucleotidase, Ecto-5′-nucleotidase
• UNSPSCコード: 12352202
• NACRES: NA.26

特性

• リコンビナント: expressed in HEK 293 cells
• 形状: frozen liquid
• 分子量: 58.6 kDa
• UniProtアクセッション番号: P21589
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... NT5E(4907)

詳細

詳細

5′-Nucleotidase/CD73 is glycosyl-phosphatidyl inositol (GPI)- anchored cell surface protein. Itis present in various tissues and cells including endothelial cells, epithelialcells, and subsets of B and T cells.

アプリケーション

5′-Nucleotidase/CD73 has been used as a standard in recombinanthuman CD73 assay.

生物化学的／生理学的作用

5′-Nucleotidase/CD73 actsas a rate-limiting enzyme to produce adenosine. It helps in upholding tissuehomeostasis by converting the adenosine triphosphate (ATP)-triggered immuneactivation to adenosine-mediated immunosuppression.CD73 is a novel immunoinhibitory protein that participates in tumor growthand metastasis. CD73 in combination with conventional therapy and/or otherimmune checkpoint inhibitors has been reported to show therapeutic effectsagainst cancer.

物理的形状

Aqueous solution

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319
• 注意書き: P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable