SRP0300

TGF-β1 Latent human

recombinant, expressed in FreeStyle^™ 293-F cells, ≥98% (SDS-PAGE)

• 別名: LAP
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• 由来生物: human
• リコンビナント: expressed in FreeStyle^™ 293-F cells
• アッセイ: ≥98% (SDS-PAGE)
• フォーム: aqueous solution
• 分子量: 25 kDa
• 包装: pkg of 5 μg
• メーカー／製品名: Invitrogen
• 保管条件: avoid repeated freeze/thaw cycles
• NCBIアクセッション番号: NM_000660
• UniProtアクセッション番号: Q14766
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... LTBP1(4052)

詳細

詳細

Human TGFβ1 (GenBank Accession No. NM_000660), amino acids 30-390 (end) with Cys33Ser mutation and N-terminal His-tag, disulfide-linked homodimers of TGFβ1 LAP and mature TGFβ1, MW= ~75kDa and 25kDa, under non-reducing conditions.
LTBP1 (latent transforming growth factor β binding protein 1) belongs to the LTBP family of proteins. The protein has 18 epidermal growth factor (EGF)-like repeats and four LTBP-like repeats. The gene is mapped to human chromosome 2p22.3.

アプリケーション

Useful for cell culture and for the study of signaling and apoptotic pathways.

生物化学的／生理学的作用

LTBP1 (latent transforming growth factor β binding protein 1) is an extracellular matrix protein which also controls TGF-β (transforming growth factor β) bioavailability. LTBP1 is mainly responsible for the folding and secretion of TGF-β, thereby adding it to the extracellular matrix. It is a target of HTRA1 (high temperature requirement protein A1), a serine protease involved in cellular signaling.

物理的形状

Lyophilized from a 0.2 μM filtered, aqueous solution.

再構成

Reconstitute in sterile PBS with 0.1% BSA. Stability: >6 months at –70°C (as a solid). Store reconstituted protein in aliquots at –80°C for up to 3 months. Avoid freeze/thaw cycles.

法的情報

FreeStyle is a trademark of Invitrogen Corp.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable