SML3817

TLR2-IN-C29

≥98% (HPLC)

• 別名: 3-[[(2-Hydroxy-3-methoxyphenyl)methylene]amino]-2-methylbenzoic acid, C29
• 実験式（ヒル表記法）: C₁₆H₁₅NO₄
• CAS番号: 363600-92-4
• 分子量: 285.29
• UNSPSCコード: 51111800
• UNSPSCコード: 12352200
• NACRES: NA.21

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: yellow to orange
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: -10 to -25°C
• SMILES記法: O=C(C1=C(C)C(N=CC2=C(O)C(OC)=CC=C2)=CC=C1)O

詳細

生物化学的／生理学的作用

TLR2-IN-C29 is a toll/IL-1 receptor resistance (TIR) domain BB loop-targeting, selective toll-like receptor 2 (TLR2) antagonist that inhibits both human TLR2/1 and TLR2/6-mediated signaling (IC50 = 37.6/19.7 μM against 50 ng/mL Pam3CSK/Pam2CSK-induced reporter signal, respectively, using HEK293T TLR2/6 or TLR2/1 transfectants), while blocking only murine TLR2/1-, but not murine TLR2/6-, mediated signaling (1h 25-50 μM C29 treatment prior to 50 ng P3C/mL or 100 ng P2C/mL for 1h in murine macrophages), nor signaling induced by other TLR agonists and TNF-α.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable